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Linn.提取物的植物化学特征及其对spp.的抗真菌活性

Phytochemical Characterization of Linn. Extracts and Their antifungal Activities against spp.

作者信息

Terças Analucia G, Monteiro Andrea de Souza, Moffa Eduardo B, Dos Santos Julliana R A, de Sousa Eduardo M, Pinto Anna R B, Costa Paola C da Silva, Borges Antonio C R, Torres Luce M B, Barros Filho Allan K D, Fernandes Elizabeth S, Monteiro Cristina de Andrade

机构信息

Departamento de Engenharia Elétrica, Programa de Doutorado em Biotecnologia da Rede Nordeste de Biotecnologia Universidade Federal do MaranhãoSão Luís, Brazil.

Laboratório de Patogênese Bacteriana, Programa de Mestrado em Biologia Parasitária, Universidade CeumaSão Luís, Brazil.

出版信息

Front Microbiol. 2017 Apr 10;8:595. doi: 10.3389/fmicb.2017.00595. eCollection 2017.

DOI:10.3389/fmicb.2017.00595
PMID:28443078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5385348/
Abstract

Linn bark is used to treat dysentery by various populations in Southeast Asian countries, and its leaves have also been used in traditional medicine to treat hepatitis in India and the Philippines. Here, the antifungal actions of crude hydro-alcoholic extract (TcHE) and fractions from leaves were assessed via the agar diffusion and microdilution tests on reference strains and clinical isolates from patients with acquired immunodeficiency syndrome (AIDS). Additionally, the potential cytotoxic effects of TcHE were assessed on cultured human peripheral blood mononuclear cells (PBMC). fractions and sub-fractions were analyzed by gas chromatography coupled to mass spectrometry with electron impact (GC/MS/EI), high-performance liquid chromatography coupled to mass spectrometry "electrospray" ionization in positive mode (HPLC/MS/MS/ESI) and hydrogen nuclear magnetic resonance (HNMR). TcHE and its fractions were able to inhibit the growth of all tested strains with the -butanol (FBuOH) fraction presenting the best antifungal activity. Testing of different FBuOH sub-fractions (SF) showed that SF10 was the most active against spp. Fractioning of SF10 demonstrated that 5 out of its 15 sub-fractions were active against spp., with SF10.5 presenting the highest activity. Chemical analysis of SF10 detected hydrolysable tannins (punicalin, punicalagin), gallic acid and flavonoid C-glycosides. Overall, the results showed that L. leaf extract, fractions and sub-fractions were antifungal against spp. and may be useful to treat diseases caused by this fungus.

摘要

东南亚国家的不同人群使用石栗树皮治疗痢疾，在印度和菲律宾，其树叶也被用于传统医学治疗肝炎。在此，通过琼脂扩散法和微量稀释法，对从获得性免疫缺陷综合征（AIDS）患者中分离出的参考菌株和临床分离株，评估了石栗树叶粗提物（TcHE）及其馏分的抗真菌作用。此外，还评估了TcHE对培养的人外周血单核细胞（PBMC）的潜在细胞毒性作用。通过气相色谱-质谱联用电子轰击（GC/MS/EI）、正模式电喷雾电离高效液相色谱-质谱联用（HPLC/MS/MS/ESI）和氢核磁共振（HNMR）对馏分和亚馏分进行了分析。TcHE及其馏分能够抑制所有测试菌株的生长，其中正丁醇馏分（FBuOH）表现出最佳的抗真菌活性。对不同的FBuOH亚馏分（SF）进行测试表明，SF10对白色念珠菌活性最强。对SF10进行分馏表明，其15个亚馏分中有5个对白色念珠菌有活性，其中SF10.5活性最高。对SF10的化学分析检测到了可水解单宁（石榴苷、鞣花酸）、没食子酸和黄酮碳苷。总体而言，结果表明石栗树叶提取物、馏分和亚馏分对白色念珠菌具有抗真菌作用，可能有助于治疗由该真菌引起的疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/861ee0baabb6/fmicb-08-00595-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/01472c558049/fmicb-08-00595-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/600262adf374/fmicb-08-00595-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/79ed695c3497/fmicb-08-00595-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/22b704e370d9/fmicb-08-00595-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/93424d832a70/fmicb-08-00595-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/d3386e22c33d/fmicb-08-00595-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/ec484f2899ca/fmicb-08-00595-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/861ee0baabb6/fmicb-08-00595-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/01472c558049/fmicb-08-00595-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/600262adf374/fmicb-08-00595-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/79ed695c3497/fmicb-08-00595-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/22b704e370d9/fmicb-08-00595-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/93424d832a70/fmicb-08-00595-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/d3386e22c33d/fmicb-08-00595-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/ec484f2899ca/fmicb-08-00595-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98b3/5385348/861ee0baabb6/fmicb-08-00595-g0008.jpg

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