Morampudi Suman, Das Neha, Gowda Arun, Patil Anand
Phamax Analytic Resources Pvt. Ltd., Bengaluru 560095, India.
Cancer Biol Med. 2017 Feb;14(1):74-82. doi: 10.20892/j.issn.2095-3941.2016.0030.
Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years (DALY) in Australia, the Philippines, and Singapore.
The years of life lost (YLL) and years lost due to disability (YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for 2015.
The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435, respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these countries.
Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.
肺癌是全球主要癌症之一及癌症死亡的主要原因。与肺癌高死亡率相关的经济负担沉重，2008年在全球范围内接近1800亿美元。本文旨在从残疾调整生命年（DALY）角度了解澳大利亚、菲律宾和新加坡肺癌的经济负担。
使用默里和洛佩兹于1996年制定的公式计算寿命损失年数（YLL）和因残疾损失年数（YLD），作为1990年疾病、损伤及风险因素死亡率和残疾率综合评估的一部分，并预测至2020年。世界卫生组织提供的全球疾病负担模板中也采用了相同公式。数据不可用时进行了适当假设，并使用回归分析进行预测以获取2015年的数据。
澳大利亚、菲律宾和新加坡因肺癌导致的DALY总数分别为91,695、38,584和12,435，相应的每千人口DALY率分别为4.0、0.4和2.2，贴现率为3%。当研究人员不采用贴现率计算DALY时，疾病负担大幅增加；澳大利亚的DALY为117,438，菲律宾为50,977，新加坡为16,379。总体而言这些国家YLL或过早死亡占DALY的95%以上。
对于主要负担源于死亡率的疾病，必须制定预防、早期诊断和及时治疗策略。
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