Department of Chemistry, Capital Normal University , Beijing 100048, P. R. China.
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, P. R. China.
Org Lett. 2017 May 5;19(9):2226-2229. doi: 10.1021/acs.orglett.7b00678. Epub 2017 Apr 26.
An iron-catalyzed dehydrogenative sp-sp coupling of acetonitrile and 2-arylimidazo[1,2-a]pyridine has been realized, which can serve as a novel approach toward heteroarylacetonitriles. The merit of this strategy is illustrated by the breadth of functional groups tolerated in the transformation and the fast access to pharmaceuticals (such as zolpidem) directly from the heteroarylacetonitriles.
实现了铁催化的乙腈和 2-芳基咪唑并[1,2-a]吡啶的 sp-sp 偶联反应，这为杂芳基乙腈的合成提供了一种新方法。该策略的优点在于反应中可容忍的官能团范围广泛，并且可直接从杂芳基乙腈快速获得药物（如唑吡坦）。
