Yokota Satoshi, Takihara Yuji, Takamura Yoshihiro, Inatani Masaru
Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji, Yoshida, Fukui, 910-1193, Japan.
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo, Kyoto, 606-8501, Japan.
BMC Ophthalmol. 2017 Apr 26;17(1):57. doi: 10.1186/s12886-017-0456-9.
To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography.
Forty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The patients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the NVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups.
In the non-NVG group, the mean age was 66.2 ± 2.4 (mean ± standard error) years, mean maximum IOP was 18.8 ± 1.8 mmHg, mean cpRNFL thickness was 91.2 ± 3.9 μm, mean ALD was 407.0 ± 22.9 μm, and mean LT was 155.0 ± 4.7 μm. In the NVG group, the mean age was 61.4 ± 2.1 years, mean maximum IOP was 33.1 ± 1.6 mmHg, mean cpRNFL thickness was 73.6 ± 3.4 μm, mean ALD was 403.9 ± 20.1 μm, and mean LT was 156.9 ± 4.2 μm. The IOP was significantly higher and the cpRNFL was significantly thinner in the NVG group (P < 0.001 and P = 0.002, respectively). However, the age, ALD, and LT were not statistically different between the groups (P = 0.151, 0.919, and 0.757, respectively).
Although the cpRNFL was thinner, the structure of the lamina cribrosa was unchanged in the NVG eyes. Axonal loss of the retinal ganglion cells in NVG patients was prior to lamina cribrosa deformation.
使用增强深度成像光谱域光学相干断层扫描技术比较新生血管性青光眼（NVG）患眼和非NVG患眼的筛板情况。
46例增殖性糖尿病视网膜病变患者纳入本横断面研究。根据是否存在NVG将患者分为两组（分别为非NVG组和NVG组）。比较两组间的眼压（IOP）、视盘周围视网膜神经纤维层（cpRNFL）厚度、筛板前深度（ALD）和筛板层厚度（LT）。
非NVG组，平均年龄为66.2±2.4（均值±标准误）岁，平均最高眼压为18.8±1.8 mmHg，平均cpRNFL厚度为91.2±3.9μm，平均ALD为407.0±22.9μm，平均LT为155.0±4.7μm。NVG组，平均年龄为61.4±2.1岁，平均最高眼压为33.1±1.6 mmHg，平均cpRNFL厚度为73.6±3.4μm，平均ALD为403.9±20.1μm，平均LT为156.9±4.2μm。NVG组的眼压显著更高，cpRNFL显著更薄（分别为P<0.001和P = 0.002）。然而，两组间的年龄、ALD和LT无统计学差异（分别为P = 0.151、0.919和0.757）。
尽管NVG患眼的cpRNFL较薄，但筛板结构未改变。NVG患者视网膜神经节细胞的轴突丢失先于筛板变形。
