短的肺移植供体端粒长度与无慢性移植肺功能障碍生存期的缩短相关。
Short lung transplant donor telomere length is associated with decreased CLAD-free survival.
作者信息
Faust Hilary E, Golden Jeffrey A, Rajalingam Raja, Wang Angelia S, Green Gary, Hays Steven R, Kukreja Jasleen, Singer Jonathan P, Wolters Paul J, Greenland John R
机构信息
Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
University of California, San Francisco, California, USA.
出版信息
Thorax. 2017 Nov;72(11):1052-1054. doi: 10.1136/thoraxjnl-2016-209897. Epub 2017 Apr 26.
Abstract
Telomere length (TL) decreases with cellular ageing and biological stressors. As advanced donor and recipient ages are risk factors for chronic lung allograft dysfunction (CLAD), we hypothesised that decreased age-adjusted donor TL would predict earlier onset of CLAD. Shorter donor TL was associated with increased risk of CLAD or death (HR 1.26 per 1 kb TL decrease, 95% CI 1.03 to 1.54), particularly for young donors. Recipient TL was associated with cytopenias but not CLAD. Shorter TL was also seen in airway epithelium for subjects progressing to CLAD (p=0.02). Allograft TL may contribute to CLAD pathogenesis and facilitate risk stratification.
摘要
端粒长度（TL）会随着细胞衰老和生物应激因素而缩短。由于供体和受体年龄较大是慢性肺移植功能障碍（CLAD）的危险因素，我们推测年龄校正后的供体TL降低会预示CLAD更早发病。供体TL较短与CLAD或死亡风险增加相关（每1 kb TL降低的风险比为1.26，95%置信区间为1.03至1.54），尤其是对于年轻供体。受体TL与血细胞减少有关，但与CLAD无关。在进展为CLAD的受试者的气道上皮中也观察到较短的TL（p=0.02）。同种异体移植的TL可能有助于CLAD的发病机制，并有助于进行风险分层。
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JCI Insight. 2016 Sep 8;1(14):e86704. doi: 10.1172/jci.insight.86704.
2
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PLoS One. 2016 Sep 2;11(9):e0162409. doi: 10.1371/journal.pone.0162409. eCollection 2016.
3
Therapeutic Targeting of Telomerase.端粒酶的治疗靶点
Genes (Basel). 2016 Jul 21;7(7):39. doi: 10.3390/genes7070039.
4
Noninvasive monitoring of infection and rejection after lung transplantation.肺移植术后感染与排斥反应的无创监测
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13336-41. doi: 10.1073/pnas.1517494112. Epub 2015 Oct 12.
5
The Registry of the International Society for Heart and Lung Transplantation: Thirty-second Official Adult Heart Transplantation Report--2015; Focus Theme: Early Graft Failure.国际心肺移植学会登记处：第三十二次成人心脏移植官方报告——2015年；重点主题：早期移植物功能衰竭
J Heart Lung Transplant. 2015 Oct;34(10):1244-54. doi: 10.1016/j.healun.2015.08.003. Epub 2015 Aug 28.
6
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J Heart Lung Transplant. 2015 Oct;34(10):1318-24. doi: 10.1016/j.healun.2015.05.002. Epub 2015 May 11.
7
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BMC Nephrol. 2015 Feb 18;16:23. doi: 10.1186/s12882-015-0014-8.
8
Association between donor leukocyte telomere length and survival after unrelated allogeneic hematopoietic cell transplantation for severe aplastic anemia.供体白细胞端粒长度与严重再生障碍性贫血无关供者异基因造血细胞移植后生存率之间的关联
JAMA. 2015 Feb 10;313(6):594-602. doi: 10.1001/jama.2015.7.
9
Bronchiolitis obliterans syndrome: the final frontier for lung transplantation.闭塞性细支气管炎综合征：肺移植的最后边界。
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10
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