Ni Xiao-Bing, Jia Cheng, Yu He-Dong, Li Yan-Qin, Zeng Xian-Tao, Leng Wei-Dong
Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China.
Department of Orthodontics, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Oncotarget. 2017 Jul 25;8(30):48996-49004. doi: 10.18632/oncotarget.16922.
Associations between interleukin-8 (IL-8) gene polymorphisms and periodontitis susceptibility have been investigated in many published studies, but the conclusions are still inconsistent. Therefore, we performed this systematic review and meta-analysis to review which polymorphisms have been researched and to obtain a precise result of the same polymorphism from different studies.
Finally 10 publications involving 1938 patients and 1569 controls were yielded, including 12 polymorphisms. Six studies investigated rs4073 polymorphism; two focused on rs2227306 and rs2227307; two referred to rs2227532 and T-738A; one detected rs2230054, rs1126579 and rs1126580; one inspected A2767T, T11722T2 and C1633T, and one for rs2234671 polymorphism. Of them, IL-8 C1633T and rs1126580 polymorphisms showed positive association while the other ten polymorphisms revealed negative results.
A comprehensive literature search from PubMed, Web of Science, and Chinese National Knowledge Infrastructure was conducted for all potentially relevant studies published before January 2, 2017. Two authors selected the studies and extracted data. The pooled analysis was conducted using the RevMan 5.1 software if a polymorphism was reported by two or more studies.
Based on current evidence, the IL-8 rs4073, A2767T, T11722T2, rs2234671, rs2230054, rs1126579, rs2227306, rs2227307, rs2227532, and T-738A polymorphisms were not associated with periodontitis susceptibility; the IL-8 C1633T and rs1126580 polymorphisms were associated with increased risk of periodontitis.
白细胞介素-8（IL-8）基因多态性与牙周炎易感性之间的关联已在许多已发表的研究中进行了调查，但结论仍不一致。因此，我们进行了这项系统评价和荟萃分析，以回顾哪些多态性已被研究，并从不同研究中获得同一多态性的精确结果。
最终纳入10篇文献，涉及1938例患者和1569例对照，包括12种多态性。6项研究调查了rs4073多态性；2项聚焦于rs2227306和rs2227307；2项涉及rs2227532和T-738A；1项检测了rs2230054、rs1126579和rs1126580；1项检查了A2767T、T11722T2和C1633T，1项研究了rs2234671多态性。其中，IL-8 C1633T和rs1126580多态性显示出正相关，而其他10种多态性显示出负相关结果。
对截至2017年1月2日发表的所有潜在相关研究，从PubMed、Web of Science和中国知网进行了全面的文献检索。由两位作者选择研究并提取数据。如果两种或更多研究报道了同一多态性，则使用RevMan 5.1软件进行汇总分析。
基于目前的证据，IL-8 rs4073、A2767T、T11722T2、rs2234671、rs2230054、rs1126579、rs2227306、rs2227307、rs2227532和T-738A多态性与牙周炎易感性无关；IL-8 C1633T和rs1126580多态性与牙周炎风险增加相关。
