Department of Prosthodontics, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Institute of Neuroscience, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2022 Mar;166(1):28-39. doi: 10.5507/bp.2021.066. Epub 2021 Dec 13.
IL-8 and its polymorphisms are involved in multiple acute and chronic inflammatory processes including pathological changes to surrounding structures of the teeth called periodontal diseases or periodontitis. The aim of this manuscript was to systematically review studies from 2006 to 2021 on IL-8 polymorphisms and their association with periodontitis. Literature analysis was done following the PRISMA protocol guidance using articles not older than 15 years (2006-2021). The search was carried out using PubMed (MEDLINE), ScienceDirect and Wiley Online Library databases. For the focus question, the PICO (population (P), intervention (I), control (C), and outcome (O)) study design protocol was used, and the following question was formulated: are IL-8 gene polymorphisms associated with periodontitis? A total of 2422 articles were found at the beginning of the search. After applying the inclusion and exclusion criteria, screening, and full-text article exclusion with reasons, 31 studies were included in the analysis. In conclusion, IL-8 and its gene polymorphisms are associated with an increased risk of periodontal diseases.
白细胞介素 8（IL-8）及其多态性参与多种急性和慢性炎症过程，包括牙齿周围结构的病理性改变，称为牙周病或牙周炎。本文的目的是系统地综述 2006 年至 2021 年期间关于白细胞介素 8 多态性及其与牙周炎关系的研究。文献分析按照 PRISMA 方案指南进行，使用不超过 15 年的文献（2006-2021 年）。检索使用了 PubMed（MEDLINE）、ScienceDirect 和 Wiley Online Library 数据库。针对重点问题，采用了 PICO（人群（P）、干预（I）、对照（C）和结局（O））研究设计方案，并提出了以下问题：白细胞介素 8 基因多态性是否与牙周炎有关？在搜索开始时，共找到了 2422 篇文章。在应用纳入和排除标准、筛选以及有原因的全文文章排除后，共有 31 项研究纳入分析。总之，白细胞介素 8 及其基因多态性与牙周病的发生风险增加有关。
