Cannatà Antonio, Marcon Gabriella, Cimmino Giovanni, Camparini Luca, Ciucci Giulio, Sinagra Gianfranco, Loffredo Francesco S
Molecular Cardiology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy.
Cardiovascular Department, Azienda Sanitaria Universitaria Integrata and University of Trieste, Trieste, Italy.
J Thorac Dis. 2017 Mar;9(Suppl 1):S17-S29. doi: 10.21037/jtd.2017.03.95.
Worldwide increase in life expectancy is a major contributor to the epidemic of chronic degenerative diseases. Aging, indeed, simultaneously affects multiple organ systems, and it has been hypothesized that systemic alterations in regulators of tissue physiology may regulate this process. Cardiac aging itself is a major risk factor for cardiovascular diseases and, because of the intimate relationship with the brain, may contribute to increase the risk of neurodegenerative disorders. Blood-borne factors may play a major role in this complex and still elusive process. A number of studies, mainly based on the revival of parabiosis, a surgical technique very popular during the 70s of the 20 century to study the effect of a shared circulation in two animals, have indeed shown the potential that humoral factors can control the aging process in different tissues. In this article we review the role of circulating factors in cardiovascular aging. A better understanding of these mechanisms may provide new insights in the aging process and provide novel therapeutic opportunities for chronic age-related disorders.
全球预期寿命的增加是慢性退行性疾病流行的一个主要因素。事实上，衰老同时影响多个器官系统，并且据推测，组织生理学调节因子的系统性改变可能会调节这一过程。心脏衰老本身就是心血管疾病的一个主要危险因素，而且由于与大脑的密切关系，可能会增加神经退行性疾病的风险。血源性因子可能在这个复杂且仍难以捉摸的过程中起主要作用。一些主要基于联体生活（一种在20世纪70年代非常流行的外科技术，用于研究两只动物共享血液循环的效果）复苏的研究确实表明，体液因子具有控制不同组织衰老过程的潜力。在本文中，我们综述了循环因子在心血管衰老中的作用。对这些机制的更好理解可能会为衰老过程提供新的见解，并为慢性年龄相关疾病提供新的治疗机会。
