Komeyama Kimihiro, Ohata Ryo, Kiguchi Shinnosuke, Osaka Itaru
Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima City, Hiroshima 739-8527, Japan.
Chem Commun (Camb). 2017 Jun 13;53(48):6401-6404. doi: 10.1039/c7cc01932g.
Reductive cross-coupling of aryl halides with ubiquitous alkyl tosylates was developed using a combination of nickel and vitamin B (VB: cyanocobalamin) catalysts. The tosylate was activated by reduced VB to form alkyl cobalt(iii), which served as a good alkylating agent for aryl-nickel species, leading to C(sp)-C(sp) bond formation.
利用镍和维生素B（VB：氰钴胺）催化剂的组合，开发了芳基卤化物与常见的烷基甲苯磺酸盐的还原交叉偶联反应。甲苯磺酸盐通过还原的VB被活化，形成烷基钴（III），其作为芳基镍物种的良好烷基化剂，导致C（sp）-C（sp）键的形成。
