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聚合型钆-多胺大环配合物两亲分子形成球形和纤维状纳米颗粒磁共振成像造影剂。

Polymeric Gd-DOTA amphiphiles form spherical and fibril-shaped nanoparticle MRI contrast agents.

作者信息

Randolph Lyndsay M, LeGuyader Clare L M, Hahn Michael E, Andolina Christopher M, Patterson Joseph P, Mattrey Robert F, Millstone Jill E, Botta Mauro, Scadeng Miriam, Gianneschi Nathan C

机构信息

Department of Chemistry and Biochemistry , University of California , 9500 Gilman Dr., La Jolla , San Diego , CA 92093 , USA . Email:

Department of Radiology , University of California , 9500 Gilman Dr., La Jolla , San Diego , CA 92093 , USA.

出版信息

Chem Sci. 2016 Jul 1;7(7):4230-4236. doi: 10.1039/c6sc00342g. Epub 2016 Mar 22.

DOI:10.1039/c6sc00342g
PMID:30155069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6013922/
Abstract

A Gd-coordinated polymerizable analogue of the MRI contrast agent Gd-DOTA was used to prepare amphiphilic block copolymers, with hydrophilic blocks composed entirely of the polymerized contrast agent. The resulting amphiphilic block copolymers assemble into nanoparticles (NPs) of spherical- or fibril-shape, each demonstrating enhanced relaxivity over Gd-DOTA. As an initial examination of their behavior , intraperitoneal (IP) injection of NPs into live mice was performed, showing long IP residence times, observed by MRI. Extended residence times for particles of well-defined morphology may represent a valuable design paradigm for treatment or diagnosis of peritoneal malignances.

摘要

一种与钆（Gd）配位的磁共振成像（MRI）造影剂Gd - DOTA的可聚合类似物被用于制备两亲性嵌段共聚物，其亲水嵌段完全由聚合后的造影剂组成。所得的两亲性嵌段共聚物组装成球形或纤维状的纳米颗粒（NP），每一种纳米颗粒相对于Gd - DOTA都表现出更高的弛豫率。作为对其行为的初步研究，将纳米颗粒经腹腔（IP）注射到活小鼠体内，通过MRI观察到纳米颗粒在腹腔内停留时间很长。形态明确的颗粒延长的停留时间可能代表了一种用于治疗或诊断腹膜恶性肿瘤的有价值的设计范例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/99bc16bb2685/c6sc00342g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/7c3c59b0d437/c6sc00342g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/6c05bcf381fa/c6sc00342g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/7c635479d642/c6sc00342g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/99bc16bb2685/c6sc00342g-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/7c3c59b0d437/c6sc00342g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/6c05bcf381fa/c6sc00342g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/7c635479d642/c6sc00342g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f6f/6013922/99bc16bb2685/c6sc00342g-f4.jpg

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