Lee Yee Ting, Laxton Victoria, Lin Hiu Yu, Chan Yin Wah Fiona, Fitzgerald-Smith Sophia, To Tsz Ling Olivia, Yan Bryan P, Liu Tong, Tse Gary
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, SAR, P.R. China.
Intensive Care Department, Royal Brompton and Harefield NHS Trust, London SW3 6NP, UK.
Biomed Rep. 2017 Mar;6(3):259-266. doi: 10.3892/br.2017.843. Epub 2017 Jan 17.
Atherosclerosis is a significant cause of morbidity and mortality globally. Many animal models have been developed to study atherosclerosis, and permit experimental conditions, diet and environmental risk factors to be carefully controlled. Pathophysiological changes can be produced using genetic or pharmacological means to study the harmful consequences of different interventions. Experiments using such models have elucidated its molecular and pathophysiological mechanisms, and provided platforms for pharmacological development. Different models have their own advantages and disadvantages, and can be used to answer different research questions. In the present review article, different species of atherosclerosis models are outlined, with discussions on the practicality of their use for experimentation.
动脉粥样硬化是全球发病和死亡的重要原因。已经开发了许多动物模型来研究动脉粥样硬化，并允许仔细控制实验条件、饮食和环境风险因素。可以使用遗传或药理学方法产生病理生理变化，以研究不同干预措施的有害后果。使用此类模型的实验阐明了其分子和病理生理机制，并为药物开发提供了平台。不同的模型有其自身的优缺点，可用于回答不同的研究问题。在本综述文章中，概述了不同种类的动脉粥样硬化模型，并讨论了其用于实验的实用性。
