Stewart R E, Swithers S E, Plunkett L M, McCarty R
Department of Psychology, University of Virginia, Charlottesville 22903-2477.
Neurosci Biobehav Rev. 1988 Summer;12(2):151-68. doi: 10.1016/s0149-7634(88)80007-1.
Atrial natriuretic factor is a recently-discovered family of biologically active peptides produced in, stored and secreted by mammalian atria. ANF exerts a wide variety of actions in the periphery as well as within the central nervous system. In general, these actions are directed toward the maintenance of body fluid and electrolyte balance and regulation of arterial blood pressure. In a fashion similar to that of many other hormonal systems, the actions of ANF in various target tissues appear to be mediated by at least one class of specific receptors. However, while the biosynthesis and biological actions of ANF have been extensively investigated, little research has been focused on ANF receptor systems. In this article, we will provide an overview of current literature regarding the distribution and binding characteristics of receptor sites for ANF in peripheral and central target tissues. In addition, we will consider factors involved in the regulation and alteration of ANF receptor sites in various tissues. Finally, a brief discussion of the emerging concept of ANF and angiotensin II as mutual antagonists in body fluid homeostasis and cardiovascular regulation will be offered.
心房利钠因子是最近发现的一类生物活性肽家族，由哺乳动物心房产生、储存和分泌。心房利钠因子在周围组织以及中枢神经系统中发挥多种作用。一般来说，这些作用旨在维持体液和电解质平衡以及调节动脉血压。与许多其他激素系统类似，心房利钠因子在各种靶组织中的作用似乎至少由一类特异性受体介导。然而，尽管心房利钠因子的生物合成和生物学作用已得到广泛研究，但对心房利钠因子受体系统的研究却很少。在本文中，我们将概述当前有关心房利钠因子受体位点在周围和中枢靶组织中的分布和结合特性的文献。此外，我们将考虑参与各种组织中心房利钠因子受体位点调节和改变的因素。最后，将简要讨论心房利钠因子和血管紧张素II作为体液稳态和心血管调节中的相互拮抗剂这一新兴概念。
