亲脂性核壳结构FeO@SiO@Au纳米粒子的合成及其聚合物包裹形成纳米胶束：一种用于体内主动靶向和磁共振-光声双成像的新型纳米系统。
Synthesis of Lipophilic Core-Shell FeO@SiO@Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging.
作者信息
Monaco Ilaria, Arena Francesca, Biffi Stefania, Locatelli Erica, Bortot Barbara, La Cava Francesca, Marini Giada Maria, Severini Giovanni Maria, Terreno Enzo, Comes Franchini Mauro
机构信息
Department of Industrial Chemistry "Toso Montanari", University of Bologna , Viale del Risorgimento 4, Bologna 40136, Italy.
Molecular and Preclinical Imaging Centers, Department of Molecular Biotechnology and Healthy Sciences, University of Torino , Via Nizza 52, Torino 10126, Italy.
出版信息
Bioconjug Chem. 2017 May 17;28(5):1382-1390. doi: 10.1021/acs.bioconjchem.7b00076. Epub 2017 May 3.
In this work, iron/silica/gold core-shell nanoparticles (FeO@SiO@Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.
在本研究中，已合成了具有磁性和光学特性的铁/二氧化硅/金核壳纳米粒子（FeO@SiO@Au NPs），以获得一个有前景的诊疗平台。为提高其生物相容性，已将所得的多层纳米粒子包裹于聚合物胶束中，用叶酸部分进行修饰，并在体内进行了卵巢癌的光声和磁共振成像检测测试。
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