Nilsson Jonas, Holgersson Georg, Carlsson Tobias, Henriksson Roger, Bergström Stefan, Bergqvist Michael
Centre for Research and Development, Uppsala University/Region Gävleborg, SE-801 87 Gävle, Sweden.
Department of Radiation Sciences and Oncology, Umeå University Hospital, SE-901 87 Umeå, Sweden.
Oncol Lett. 2017 Apr;13(4):2831-2837. doi: 10.3892/ol.2017.5770. Epub 2017 Feb 23.
The focus of the present review is to investigate whether there is a variation in the incidence rates between male and female patients with high-grade primary brain tumors and if there are altered incidence rates associated with the time at which they were diagnosed. Previous studies identified in internationally peer-reviewed journals were identified using a systematic search of the PubMed database. Due to the difficulties in data interpretation, studies that exclusively included patient data classified prior to the 2nd edition of the World Health Organization histological classification system of brain tumors were excluded. The overall incidence rates and incidence trends of male and female patients were analyzed separately. The mean age-adjusted overall incidence rate in the male population was 1.27 per 100,000 compared with 0.89 per 100,000 in the female population. The variance between the two genders differed and a Wilcoxon rank-sum test indicated that there was no significant difference in the incidence rate of high-grade primary brain tumors between males and females (P=0.3658). Furthermore, there was no significant difference in incidence rate trend between 1996-2004 and 2005-2010 for male or female populations (P=0.101 and P=0.472, respectively). The results from the present systematic review did not demonstrate a significant difference in incidence rate between the two genders. Therefore, the results from the current study are considered to be preliminary and further studies are required to elucidate this issue.
本综述的重点是调查高级别原发性脑肿瘤男性和女性患者的发病率是否存在差异，以及发病率是否与诊断时间相关。通过对PubMed数据库进行系统检索，确定了国际同行评审期刊上发表的先前研究。由于数据解释存在困难，专门纳入世界卫生组织脑肿瘤组织学分类系统第二版之前分类的患者数据的研究被排除。分别分析了男性和女性患者的总体发病率和发病趋势。男性人群中经年龄调整的平均总体发病率为每10万人口1.27例，而女性人群为每10万人口0.89例。两性之间的差异不同，Wilcoxon秩和检验表明，高级别原发性脑肿瘤的发病率在男性和女性之间没有显著差异（P = 0.3658）。此外，1996 - 2004年和2005 - 2010年期间，男性或女性人群的发病率趋势也没有显著差异（分别为P = 0.101和P = 0.472）。本系统综述的结果并未显示两性之间的发病率存在显著差异。因此，本研究的结果被认为是初步的，需要进一步的研究来阐明这个问题。
