Nguyen Thao T P, Bhandari Bhesh, Cichero Julie, Prakash Sangeeta
School of Agriculture and Food Sciences, The University of Queensland, Brisbane, Australia.
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, Australia.
Food Res Int. 2015 Oct;76(Pt 3):373-386. doi: 10.1016/j.foodres.2015.07.016. Epub 2015 Jul 17.
Although mothers' milk is the best food for babies, infant formula has become an alternative when breastfeeding is not possible or inadequate for babies. To design a proper formula for babies, understanding digestibility of macronutrients and their bio-accessibility in the gastrointestinal tract is essential. In vivo gastrointestinal studies on human infants are restricted by ethical constraint, cost issues, and intensive resource. However, in vitro models offer many advantages with low cost, easy sampling accessibility and no ethical issues. This article aims at reviewing the main aspects of the infant physiological gastrointestinal tract and providing an insight on recent in vitro research on infant formula.
尽管母乳是婴儿的最佳食物，但当无法进行母乳喂养或母乳喂养对婴儿不足时，婴儿配方奶粉已成为一种替代选择。为婴儿设计合适的配方奶粉，了解宏量营养素在胃肠道中的消化率及其生物可利用性至关重要。对人类婴儿进行的体内胃肠道研究受到伦理限制、成本问题和资源密集的制约。然而，体外模型具有成本低、采样容易且无伦理问题等诸多优点。本文旨在综述婴儿生理性胃肠道的主要方面，并深入探讨近期关于婴儿配方奶粉的体外研究。
