Castillo Sebastian, Muñoz Patricia, Behrens Maria Isabel, Diaz-Grez Fernando, Segura-Aguilar Juan
Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile.
Neurotox Res. 2017 Aug;32(2):172-174. doi: 10.1007/s12640-017-9736-7. Epub 2017 Apr 29.
To explore the possible influence of heavy metal mining on incidence of Parkinson's disease (PD), global DNA methylation was assessed in blood samples from a population of PD patients (n = 45) and control subjects (n = 52) in Antofagasta neighborhood, a Chilean city built for exclusive use of mining companies. Comparisons were made with PD subjects (n = 52) and control subjects (n = 59) from Santiago Chile, a city having little association with mining. All subjects were assessed by two neurologists and PD diagnosis was based on UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria. From blood samples obtained from each individual, a decrease in global DNA methylation was observed in PD patients either exposed (49% of control, P < 0.001) or not exposed (47% of control, P < 0.001) to mining activity. Although there was no difference in levels of DNA methylation between PD patients from the two cities, there was a lower level of DNA methylation in control subjects from Santiago versus Antofagasta.
为探究重金属开采对帕金森病（PD）发病率的可能影响，对来自智利一个专为矿业公司建造的城市安托法加斯塔社区的一组帕金森病患者（n = 45）和对照受试者（n = 52）的血液样本进行了全基因组DNA甲基化评估。并与来自智利圣地亚哥的帕金森病受试者（n = 52）和对照受试者（n = 59）进行了比较，圣地亚哥与矿业几乎没有关联。所有受试者均由两名神经科医生进行评估，PD诊断基于英国帕金森病协会脑库临床诊断标准。在从每个个体采集的血液样本中，无论是暴露于（对照的49%，P < 0.001）还是未暴露于（对照的47%，P < 0.001）采矿活动的帕金森病患者中，均观察到全基因组DNA甲基化水平降低。尽管两个城市的帕金森病患者之间的DNA甲基化水平没有差异，但圣地亚哥对照受试者的DNA甲基化水平低于安托法加斯塔对照受试者。
