慢性阻塞性肺疾病患者自我报告的每日步行时间：与相关临床和功能特征的关系
Self-reported daily walking time in COPD: relationship with relevant clinical and functional characteristics.
作者信息
Ramon Maria A, Esquinas Cristina, Barrecheguren Miriam, Pleguezuelos Eulogio, Molina Jesús, Quintano José A, Roman-Rodríguez Miguel, Naberan Karlos, Llor Carl, Roncero Carlos, Miravitlles Marc
机构信息
Department of Pneumology, Vall d'Hebron University Hospital.
Faculty of Medicine, Autonomous University of Barcelona.
出版信息
Int J Chron Obstruct Pulmon Dis. 2017 Apr 13;12:1173-1181. doi: 10.2147/COPD.S128234. eCollection 2017.
BACKGROUND
Quantifying physical activity in chronic obstructive pulmonary disease (COPD) is important as physical inactivity is related to poor health outcomes. This study analyzed the relationship between patients' self-reported daily walking time and relevant characteristics related to COPD severity.
METHODS
Pooled analysis was performed on data from four observational studies on which daily walking time was gathered from a personal interview. Patients were classified as physically inactive if walking time was <30 min/day. Walking times were described and compared according to several markers of disease severity.
RESULTS
The mean daily walking time of 5,969 patients was 66 (standard deviation [SD] 47) min/day; 893 (15%) patients were inactive. A linear dose-response relationship was observed between walking time and the modified Medical Research Council (mMRC) dyspnea score, admissions, COPD assessment test (CAT), body mass index, airway obstruction, dyspnea, exacerbation (BODEx) index, and Charlson index (<0.001). Daily walking times were lower in patients classified as Global Initiative for Chronic Obstructive Lung Disease (GOLD) B and D (<0.001). Often, inactive patients had mMRC or Charlson index >3, post-bronchodilator forced expiratory volume in the first second <30% predicted, at least one hospitalization for COPD, classified as GOLD B or D, BODEx >4, and CAT score >30.
CONCLUSION
Lower self-reported walking times are related to worse markers of disease severity in COPD.
背景
由于缺乏身体活动与不良健康结局相关，因此对慢性阻塞性肺疾病（COPD）患者的身体活动进行量化很重要。本研究分析了患者自我报告的每日步行时间与COPD严重程度相关特征之间的关系。
方法
对四项观察性研究的数据进行汇总分析，这些研究通过个人访谈收集每日步行时间。如果步行时间<30分钟/天，则将患者分类为身体活动不足。根据疾病严重程度的几个指标对步行时间进行描述和比较。
结果
5969例患者的平均每日步行时间为66（标准差[SD]47）分钟/天；893例（15%）患者身体活动不足。观察到步行时间与改良医学研究委员会（mMRC）呼吸困难评分、住院次数、COPD评估测试（CAT）、体重指数、气道阻塞、呼吸困难、加重（BODEx）指数和Charlson指数之间存在线性剂量反应关系（<0.001）。在全球慢性阻塞性肺疾病倡议（GOLD）B级和D级患者中，每日步行时间较低（<0.001）。通常，身体活动不足的患者mMRC或Charlson指数>3，支气管扩张剂使用后第一秒用力呼气量<预测值的30%，至少因COPD住院一次，分类为GOLD B级或D级，BODEx>4，CAT评分>30。
结论
自我报告的步行时间较短与COPD患者疾病严重程度的较差指标相关。
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