Liu Feng, Wang Wei, Yang Lei, Wang Benjie, Wang Jianchuan, Chai Weifang, Zhao Dewei
Zunyi Medical College Graduate School, Guizhou Sheng, China.
Department of Orthopaedics, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China.
J Res Med Sci. 2017 Feb 16;22:15. doi: 10.4103/1735-1995.200273. eCollection 2017.
Osteonecrosis of the femoral head (ONFH) is a common disease with high disability rate. However, a few studies investigate the etiology and clinical characteristics of nontraumatic ONFH patients in China. Therefore, we conducted this cross-sectional study.
Totally, information of 7268 nontraumatic ONFH patients treated between August 2005 and August 2015 was extracted from the medical records. The extracted information included the age, gender, diagnostic criteria, cause of nontraumatic ONFH, types of steroid use, and types of alcohol.
Among these included patients, there were 5126 (70.5%) male patients with average age of 44.5 years and 2142 (29.5%) female patients with average age of 47.6 years ( = 0.54). The number of steroid-, alcohol-, steroid/alcohol-, and idiopathic-induced nontraumatic ONFH men patients was 1684, 2310, 364, and 768, respectively, and nontraumatic ONFH women patients was 1058, 482, 140, and 462, respectively. Meanwhile, we found that both the levels of triglycerides ( = 0.03) and low-density lipoprotein ( = 0.02) were significantly changed in the idiopathic-induced nontraumatic ONFH patients.
These results indicated the earlier onset of nontraumatic ONFH in male patients than in female patients, different main etiology for male (alcohol consumption) and female (steroid use) patients, and close relationship between the lipid metabolism and idiopathic-induced nontraumatic ONFH. Our findings could be helpful for researchers to investigate the pathogenesis of ONFH and aid the clinicians in the early prevention and diagnosis of nontraumatic ONFH.
股骨头坏死（ONFH）是一种常见疾病，致残率高。然而，在中国，很少有研究调查非创伤性ONFH患者的病因和临床特征。因此，我们开展了这项横断面研究。
共从病历中提取了2005年8月至2015年8月期间接受治疗的7268例非创伤性ONFH患者的信息。提取的信息包括年龄、性别、诊断标准、非创伤性ONFH的病因、使用的类固醇类型和饮酒类型。
在纳入的这些患者中，有5126例（70.5%）男性患者，平均年龄44.5岁，2142例（29.5%）女性患者，平均年龄47.6岁（P = 0.54）。类固醇、酒精、类固醇/酒精和特发性诱发的非创伤性ONFH男性患者数量分别为1684例、2310例、364例和768例，非创伤性ONFH女性患者数量分别为1058例、482例、140例和462例。同时，我们发现特发性诱发的非创伤性ONFH患者的甘油三酯水平（P = 0.03）和低密度脂蛋白水平（P = 0.02）均有显著变化。
这些结果表明，非创伤性ONFH男性患者的发病年龄早于女性患者，男性（饮酒）和女性（使用类固醇）患者的主要病因不同，且脂质代谢与特发性诱发的非创伤性ONFH密切相关。我们的研究结果有助于研究人员探究ONFH的发病机制，并帮助临床医生对非创伤性ONFH进行早期预防和诊断。
