Coletti Dario, Adamo Sergio, Moresi Viviana
Sorbonne Universités, UPMC Univ Paris 06 (CNRS, UMR 8256, INSERM ERL U1164), Institut Biologie Paris-Seine, Paris, France.
Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome, Italy.
Eur J Transl Myol. 2017 Mar 27;27(1):6483. doi: 10.4081/ejtm.2017.6483. eCollection 2017 Feb 24.
Invited Letter to the Editor. Physical activity has multiple beneficial effects in the physiology and pathology of the organism. In particular, we and other groups have shown that running counteracts cancer cachexia in both humans and rodents. The latter are prone to exercise in wheel-equipped cages even at advanced stages of cachexia. However, when we wanted to replicate the experimental model routinely used at the University of Rome in a different laboratory (i.e. at Paris 6 University), we had to struggle with puzzling results due to unpredicted mouse behavior. Here we report the experience and offer the explanation underlying these apparently irreproducible results. The original data are currently used for teaching purposes in undergraduate student classes of biological sciences.
致编辑的邀请信。体育活动对机体的生理和病理具有多种有益作用。特别是，我们和其他研究小组已经表明，跑步可对抗人类和啮齿动物的癌症恶病质。即使在恶病质晚期，后者也倾向于在配备轮子的笼子里运动。然而，当我们想要在另一个实验室（即巴黎第六大学）复制罗马大学常规使用的实验模型时，由于小鼠行为不可预测，我们不得不应对令人困惑的结果。在此，我们报告这一经历并对这些明显无法重复的结果背后的原因作出解释。原始数据目前用于生物科学本科学生课程的教学目的。
