肌醇脂质的水解：人巨细胞病毒感染的早期信号。
Hydrolysis of inositol lipids: an early signal of human cytomegalovirus infection.
作者信息
Valyi-Nagy T, Bandi Z, Boldogh I, Albrecht T
机构信息
Department of Microbiology, University of Texas Medical Branch, Galveston.
出版信息
Arch Virol. 1988;101(3-4):199-207. doi: 10.1007/BF01311001.
The production of inositol 1,4,5-triphosphate (IP 3) and 1,2-diacylglycerol (DG) as an early cellular response to human cytomegalovirus (HCMV) infection was investigated in human embryo lung (LU) cells. The results obtained show transient 85 and 30% increases in IP3 and DG, respectively, 20 min post-exposure to HCMV. Following heat inactivation or serum neutralization of HCMV stock or in the presence of papaverine we failed to detect increased levels of IP3 and DG relative to mock-infected LU cultures.
在人胚肺（LU）细胞中研究了作为对人巨细胞病毒（HCMV）感染的早期细胞反应的肌醇1,4,5 - 三磷酸（IP₃）和1,2 - 二酰甘油（DG）的产生。获得的结果显示，在暴露于HCMV后20分钟，IP₃和DG分别瞬时增加85%和30%。在对HCMV毒株进行热灭活或血清中和后，或在存在罂粟碱的情况下，相对于模拟感染的LU培养物，我们未能检测到IP₃和DG水平的升高。
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