School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Department of Pharmacology, College of Pharmacy, University of Sargodha, Sargodha, Punjab, Pakistan.
Arch Physiol Biochem. 2022 Oct;128(5):1202-1208. doi: 10.1080/13813455.2020.1762661. Epub 2020 May 15.
Lam. has been used traditionally for the treatment of different cardio-metabolic disorders. So, the aim was to assess its leaf extracts in metabolic syndrome rat model. Out of the total 36-rats, 6 rats were given normal matched diet (NMD) while the rest were provided high-fat diet and 20% fructose (HFD-20%F). leaf extracts were administered orally for 30 days. Body weight, blood glucose, BMI, blood pressure, lipids, insulin, insulin resistance, MCP-1, visceral fat and liver weight were evaluated. Sixty-days feeding with HFD-20%F produced the metabolic syndrome features like hyperinsulinemia, insulin resistance, and increase in low-density lipoprotein (LDL), visceral fat, and liver weight significantly (<.05) than the rats receiving (NMD). treatment for 30 days significantly provided the mitigation against metabolic syndrome features. Lam. leaf extract might be a good alternative herbal choice in the treatment of metabolic syndrome disease.
腊梅传统上被用于治疗各种心脏代谢紊乱。因此,本研究旨在评估其叶片提取物对代谢综合征大鼠模型的作用。36 只大鼠中,6 只给予正常匹配饮食(NMD),其余给予高脂肪饮食和 20%果糖(HFD-20%F)。叶片提取物经口给予 30 天。评估体重、血糖、BMI、血压、血脂、胰岛素、胰岛素抵抗、MCP-1、内脏脂肪和肝重。60 天的 HFD-20%F 喂养显著产生代谢综合征特征,如高胰岛素血症、胰岛素抵抗以及低密度脂蛋白(LDL)、内脏脂肪和肝重增加(<0.05),而给予 NMD 的大鼠则没有。30 天的治疗显著减轻了代谢综合征特征。腊梅叶片提取物可能是治疗代谢综合征疾病的一种很好的替代草药选择。