Research Unit of Active Biomolecules Valorisation, Higher Institute of Applied Biology of Medenine (ISBAM), University of Gabes, 4119 Medenine, Tunisia.
Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia.
Biomed Res Int. 2020 Feb 27;2020:6583603. doi: 10.1155/2020/6583603. eCollection 2020.
The consumption of a high-fat diet is linked to the development of obesity and considered a risk factor for cardiovascular diseases. The aim of this study was to evaluate the effect of the methanolic extract of leaves (MEML) on the high-fat diet- (HFD-) induced obesity and cardiac damage in rats. MEML, at a dose of 200 mg/kg/bw and 400 mg/kg/bw, was orally administrated to obese rats for 12 weeks. . leaves were proved to be rich in nutrients and minerals. Diversity of phenolic compounds in MEML was evidenced via LC-ESI-MS analysis. The chronic administration of HFD in rats led to an increase in the body weight gain, total cholesterol, and triglycerides and reduction in the HDL-C levels. The obtained results indicated a significant increase ( < 0.05) in the cardiac marker enzyme level in obese rats. A significant decrease ( < 0.05) in the levels of cardiac catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities was accompanied with an increase of malondialdehyde (MDA) level in the high-fat diet group when compared to those of the control. The treatment with the MEML alleviated abnormalities in the serum biochemical parameters, balanced the antioxidant status, and reestablished the normal histological structure of the heart especially in the case of the higher concentration. leaves may be a promising candidate in the management of obesity and its related complications such as heart problems.
高脂肪饮食的摄入与肥胖的发生有关，被认为是心血管疾病的一个风险因素。本研究旨在评估叶甲醇提取物（MEML）对高脂肪饮食（HFD）诱导的肥胖和大鼠心脏损伤的影响。MEML 以 200mg/kg/bw 和 400mg/kg/bw 的剂量口服给予肥胖大鼠 12 周。结果表明， 叶富含营养物质和矿物质。通过 LC-ESI-MS 分析证明 MEML 中酚类化合物的多样性。HFD 慢性给药导致大鼠体重增加、总胆固醇和甘油三酯增加，高密度脂蛋白胆固醇（HDL-C）水平降低。结果表明，肥胖大鼠的心脏标志物酶水平显著升高（<0.05）。与对照组相比，高脂肪饮食组的心脏过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶（SOD）活性水平显著降低（<0.05），同时丙二醛（MDA）水平升高。MEML 治疗可改善血清生化参数异常，平衡抗氧化状态，恢复心脏的正常组织学结构，尤其是在较高浓度时。 叶可能是肥胖及其相关并发症（如心脏问题）管理的有前途的候选药物。
