Université Paris 13, Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre d'Epidémiologie et Statistiques Sorbonne Paris Cité, Inserm (U1153), Inra (U1125), Bobigny, France.
Département de Santé Publique, Hôpital Avicenne, Bobigny, France.
J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):347-354. doi: 10.1093/gerona/glx066.
The Mediterranean diet has been suggested as a key element for the prevention of age-related chronic diseases. However, very few studies have examined its relation with multidimensional concepts of healthy aging (HA). Our objective was thus to investigate the association between adherence to the Mediterranean diet at midlife and HA.
We analyzed data from 3,012 participants of the French SUpplémentation en Vitamines et Minéraux AntioXydants (SU.VI.MAX) study aged 45-60 years at baseline (1994-1995) and initially free of major chronic diseases, with available data on HA status in 2007-2009. We defined HA as not developing major chronic disease (cancer, cardiovascular disease, or diabetes), good physical and cognitive functioning (evaluated by validated, standardized tests), independence in instrumental activities of daily living, no depressive symptoms, good social functioning, good self-perceived health, and no function-limiting pain. An index assessing adherence to the Mediterranean diet, the Literature-based Adherence Score to the Mediterranean Diet (LAMD) was calculated using baseline data from repeated 24-hour dietary records.
In 2007-2009, 38% of participants met the HA criteria. Multivariable logistic regression revealed that higher scores on the LAMD (ORTertile 3 vs Tertile 1: 1.36 [1.12; 1.65]) were associated with higher odds of HA. Supplementary analyses using structural equation modeling revealed a potential mediation of the observed associations by metabolic health-related factors.
Our results suggest a favorable role of a high adherence to the Mediterranean diet at midlife for maintaining good overall health during aging.
地中海饮食被认为是预防与年龄相关的慢性疾病的关键因素。然而，很少有研究调查其与健康老龄化的多维概念的关系。我们的目的是研究中年时期遵循地中海饮食与健康老龄化之间的关系。
我们分析了法国 SUpplémentation en Vitamines et Minéraux AntioXydants（SU.VI.MAX）研究的 3012 名参与者的数据，这些参与者在基线时（1994-1995 年）年龄在 45-60 岁，且最初没有重大慢性疾病，并且在 2007-2009 年有关于健康老龄化状况的数据。我们将健康老龄化定义为不发生重大慢性疾病（癌症、心血管疾病或糖尿病）、身体和认知功能良好（通过经过验证的标准化测试评估）、独立进行日常生活活动、无抑郁症状、社会功能良好、自我感知健康状况良好和无功能受限的疼痛。使用基线时重复 24 小时饮食记录的数据计算评估地中海饮食依从性的文献基础地中海饮食依从性评分（LAMD）。
在 2007-2009 年，38%的参与者符合健康老龄化标准。多变量逻辑回归显示，LAMD 评分较高（ORTertile 3 与 Tertile 1：1.36 [1.12；1.65]）与健康老龄化的几率较高相关。使用结构方程模型进行的补充分析表明，观察到的关联可能由代谢健康相关因素介导。
我们的研究结果表明，中年时期高度遵循地中海饮食可能对保持老年期整体健康具有有益作用。
