Bonina L, Arena A, Liberto M C, Iannello D, Merendino R A, Costa G B, Mastroeni P
Institute of Medical Microbiology, Messina University, Italy.
G Batteriol Virol Immunol. 1988 Jan-Dec;81(1-12):10-24.
The antiviral activities of normal rat peritoneal macrophages versus Herpes Simplex Virus type 1 were inhibited by sera from tumor-bearing rats and 3M KCl extracts of tumor mass. The inhibitory activity was demonstrated on the extrinsic as well as on the intrinsic macrophage functions. Sera from Corynebacterium parvum and Listeria monocytogenes treated tumor bearing rats did not inhibit these macrophages functions. Furthermore the 3 M KCl extracts from the tumor mass of the above treated TBR show a decrease in the capability to impair these macrophage functions. On the other hand, the treatment with the oral polyvalent adjuvant "Buccalin" was not able to restore the compromised antiviral activity in tumor bearing rats.
荷瘤大鼠的血清以及肿瘤块的3M KCl提取物可抑制正常大鼠腹腔巨噬细胞对1型单纯疱疹病毒的抗病毒活性。这种抑制活性在外源性和内源性巨噬细胞功能上均有体现。经短小棒状杆菌和单核细胞增生李斯特菌处理的荷瘤大鼠的血清并未抑制这些巨噬细胞功能。此外，上述经处理的荷瘤大鼠肿瘤块的3M KCl提取物损害这些巨噬细胞功能的能力有所下降。另一方面，口服多价佐剂“布卡林”治疗并不能恢复荷瘤大鼠受损的抗病毒活性。
