Hørslev-Petersen K, Bentsen K D, Halberg P, Junker P, Kivirikko K I, Majamaa K, Risteli L, Risteli J, Lorenzen I
Department of Medicine, University of Copenhagen, Hvidovre Hospital, Denmark.
Clin Exp Rheumatol. 1988 Apr-Jun;6(2):129-34.
The serum levels of aminoterminal type III procollagen peptide (S-PIIINP), immunoreactive prolyl 4-hydroxylase protein (S-IRPH), 7S domain of collagen type IV (S-Col IV, 7S), and fragment P1 of laminin (S-Lam), which are associated with the metabolism of extracellular interstitial collagens and basement membranes, were measured sequentially for two years in 14 rheumatoid arthritis (RA) patients undergoing disease modifying antirheumatic drug treatment. Elevated S-PIIINP, S-IRPH, and S-Col IV, 7S levels were demonstrated in active RA. In active disease the metabolites showed some correlation with clinical and serological signs of disease activity. A high average synovial fluid/serum concentration ratio of PIIINP and of Col IV, 7S supports the concept that the increased serum levels of PIIINP and Col IV, 7S originated from the diseased joints. After 2 years of treatment a decline was observed in S-PIIINP and S-Col IV, 7S in treatment responders. However, the median levels of S-PIIINP and S-IRPH were still above the upper limit of normal, suggesting smouldering, subclinical inflammatory processes. S-Lam remained within the normal range in active and inactive disease.
在14名接受改善病情抗风湿药物治疗的类风湿关节炎（RA）患者中，连续两年对与细胞外间质胶原和基底膜代谢相关的血清氨基端III型前胶原肽（S-PIIINP）、免疫反应性脯氨酰4-羟化酶蛋白（S-IRPH）、IV型胶原7S结构域（S-Col IV，7S）和层粘连蛋白片段P1（S-Lam）水平进行了测定。在活动性RA中，S-PIIINP、S-IRPH和S-Col IV，7S水平升高。在活动性疾病中，这些代谢产物与疾病活动的临床和血清学指标存在一定相关性。PIIINP和Col IV，7S的滑膜液/血清平均浓度比值较高，支持了PIIINP和Col IV，7S血清水平升高源自患病关节的观点。治疗2年后，治疗有反应者的S-PIIINP和S-Col IV，7S水平下降。然而，S-PIIINP和S-IRPH的中位数水平仍高于正常上限，提示存在隐匿性、亚临床炎症过程。S-Lam在活动性和非活动性疾病中均保持在正常范围内。
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