Guseva N G, Anikina N V, Myllylä R, Risteli L, Risteli J, Chochlova J V, Kivirikko K I, Nassonova V A
Institute of Rheumatology, USSR Academy of Medical Sciences, Moscow.
Ann Rheum Dis. 1991 Jul;50(7):481-6. doi: 10.1136/ard.50.7.481.
The concentrations of the amino terminal propeptide of type III procollagen, the 7S domain of type IV collagen, and the fragment P1 of laminin (PIIINP, 7S, and P1 respectively) and the activity of galactosylhydroxylysyl glucosyltransferase (GGT) in serum were evaluated as indicators of disease activity in a cross sectional study of 84 patients with progressive systemic sclerosis. The mean values of PIIINP, P1, and GGT were raised in progressive systemic sclerosis, 19-32% of patients having abnormal values of the various tests. PIIINP, measured with two different assays, and P1 were associated with active, acute, or subacute disease. GGT also correlated positively with some acute phase proteins in the whole group, without a clear association with the course of the disease. Arthritis was associated with increased PIIINP concentrations as well as with an increased activity of GGT. Kidney disease led to raised concentrations of the degradation products of PIIINP. Raynaud's phenomenon in the hands was related to increased PIIINP concentrations.
在一项针对84例进行性系统性硬化症患者的横断面研究中，评估了血清中III型前胶原氨基末端前肽、IV型胶原7S结构域和层粘连蛋白片段P1（分别为PIIINP、7S和P1）的浓度以及半乳糖基羟赖氨酰葡糖基转移酶（GGT）的活性，作为疾病活动的指标。进行性系统性硬化症患者中PIIINP、P1和GGT的平均值升高，19% - 32%的患者各项检测值异常。用两种不同检测方法测得的PIIINP和P1与活动性、急性或亚急性疾病相关。GGT在整个组中也与一些急性期蛋白呈正相关，与疾病进程无明显关联。关节炎与PIIINP浓度升高以及GGT活性增加有关。肾脏疾病导致PIIINP降解产物浓度升高。手部雷诺现象与PIIINP浓度增加有关。
