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青少年首次创伤性髌骨脱位的经济决策模型

Economic Decision Model for First-Time Traumatic Patellar Dislocations in Adolescents.

作者信息

Nwachukwu Benedict U, So Conan, Schairer William W, Shubin Stein Beth E, Strickland Sabrina M, Green Daniel W, Dodwell Emily R

机构信息

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, New York, USA.

University of Maryland School of Medicine, Baltimore, Maryland, USA.

出版信息

Am J Sports Med. 2017 Aug;45(10):2267-2275. doi: 10.1177/0363546517703347. Epub 2017 May 2.

Abstract

BACKGROUND

The surgical management of traumatic patellar dislocations in adolescents is associated with a lower rate of recurrent dislocations compared with nonoperative care. However, the attendant cost of surgery and the quality-of-life benefit of a surgical treatment strategy are unclear.

PURPOSE

To compare the cost-utility of 3 management strategies for acute first-time patellar dislocations in adolescents: (1) nonoperative treatment only, (2) initial nonoperative treatment with surgery only for recurrent dislocations, and (3) immediate surgery.

STUDY DESIGN

Economic and decision analysis; Level of evidence, 2.

METHODS

A 10-year state-transition Markov model was constructed to compare the cost-utility of the 3 index treatment protocols. Utilities used to define health states were derived from a telephone interview of 60 adolescents with a history of acute patellar dislocations. The probability of transition between each health state was informed by the available literature. Direct costs were estimated using a statewide ambulatory surgery database, and indirect costs were estimated based on parental lost productivity. Effectiveness was expressed in quality-adjusted life years (QALYs). The principal outcome measure was the incremental cost-effectiveness ratio (ICER).

RESULTS

In the base case for our model, nonoperative treatment only was the least costly ($7300) but also the least effective (5.30 QALYs); initial nonoperative treatment with delayed surgery cost $10,500 for a 5.93 QALY benefit, while immediate surgical treatment cost $17,100 and provided 6.32 QALY benefits. Compared with nonoperative treatment only, initial nonoperative treatment with delayed surgery was associated with an ICER of $5100 per QALY. When immediate surgery was compared with a strategy of delayed surgery, immediate surgery provided incremental benefits at an ICER of $17,000 per QALY. The model was sensitive to the probability of surgical versus nonoperative treatment to achieve a full return to preinjury activity versus an intermediate lower state. When the probability of achieving a full return to preinjury activity with initial nonoperative treatment exceeds 47.5% (compared with 34.2% in the base case), then initial nonoperative treatment with delayed surgery is preferred to immediate surgery. Similarly, when the probability of achieving a full return to full preinjury activity with surgery falls below 51% (compared with 64% in the base case), then delayed surgery after initial nonoperative treatment is preferred.

CONCLUSION

Immediate surgery and delayed surgical treatment are both cost-effective treatment options; however, immediate surgical treatment provides the highest QALY gains within a 10-year time horizon. Our model sensitivity analysis highlights the role of optimizing functional and quality-of-life benefits in the treatment of acute traumatic patellar dislocations. These findings have implications for clinical guidelines and policy decisions relating to adolescent patellar dislocations.

摘要

背景

与非手术治疗相比,青少年创伤性髌骨脱位的手术治疗复发性脱位的发生率较低。然而,手术的相关费用以及手术治疗策略对生活质量的益处尚不清楚。

目的

比较青少年首次急性髌骨脱位的三种治疗策略的成本效益:(1)仅非手术治疗;(2)初始非手术治疗,仅对复发性脱位进行手术;(3)立即手术。

研究设计

经济与决策分析;证据级别,2级。

方法

构建一个10年的状态转换马尔可夫模型,以比较三种指标治疗方案的成本效益。用于定义健康状态的效用值来自对60名有急性髌骨脱位病史的青少年的电话访谈。每个健康状态之间转换的概率参考现有文献。直接成本使用全州门诊手术数据库进行估算,间接成本根据父母的生产力损失进行估算。有效性以质量调整生命年(QALY)表示。主要结局指标是增量成本效益比(ICER)。

结果

在我们模型的基础案例中,仅非手术治疗成本最低(7300美元),但效果也最差(5.30个QALY);初始非手术治疗并延迟手术的成本为10500美元,获得5.93个QALY的益处,而立即手术治疗成本为17100美元,提供6.32个QALY的益处。与仅非手术治疗相比,初始非手术治疗并延迟手术的ICER为每QALY 5100美元。当将立即手术与延迟手术策略进行比较时,立即手术以每QALY 17000美元的ICER提供增量益处。该模型对手术与非手术治疗实现完全恢复到伤前活动状态与中等较低状态的概率敏感。当初始非手术治疗实现完全恢复到伤前活动状态的概率超过47.5%(与基础案例中的34.2%相比)时,那么初始非手术治疗并延迟手术优于立即手术。同样,当手术实现完全恢复到伤前活动状态的概率低于51%(与基础案例中的64%相比)时,那么初始非手术治疗后延迟手术更可取。

结论

立即手术和延迟手术治疗都是具有成本效益的治疗选择;然而,在10年的时间范围内,立即手术治疗提供了最高的QALY增益。我们的模型敏感性分析突出了在急性创伤性髌骨脱位治疗中优化功能和生活质量益处的作用。这些发现对与青少年髌骨脱位相关的临床指南和政策决策具有启示意义。

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