Williamson S A, Knight R A, Lightman S L, Hobbs J R
Dept. of Chemical Immunology, Charing Cross and Westminster Medical School, London, U.K.
Immunology. 1988 Sep;65(1):47-51.
Synthetic human beta endorphin shows a biphasic effect on the production of specific anti-herpes viral antibodies in vitro. At higher concentrations antibody production is reduced, at lower concentrations it is enhanced. In a proportion of donors whose cells do not produce specific antibody when cultured with antigen alone, the lower concentrations of beta endorphin allow antigen-driven specific antibody production to occur. Specific anti-herpes viral antibodies are also made by natural killer (NK) cell-depleted populations from the same non-producer donors. beta endorphin also exerts biphasic effects on NK, although the direction of the modulation is a mirror image of the effects on antibody production. This suggests that the immunomodulatory actions of beta endorphin on specific immune responses are mediated in part by effects on NK suppressor-inducer cells.
合成人β-内啡肽在体外对特异性抗疱疹病毒抗体的产生呈现出双相效应。在较高浓度时抗体产生减少，在较低浓度时则增强。在一部分供体中，其细胞单独与抗原培养时不产生特异性抗体，较低浓度的β-内啡肽能使抗原驱动的特异性抗体产生。来自相同不产生抗体的供体的自然杀伤（NK）细胞耗尽群体也能产生特异性抗疱疹病毒抗体。β-内啡肽对NK也有双相效应，尽管调节方向与对抗体产生的效应呈镜像关系。这表明β-内啡肽对特异性免疫反应的免疫调节作用部分是通过对NK抑制诱导细胞的作用介导的。
