恶性疟原虫对过氧化物酶介导的氧依赖性杀菌系统的敏感性。
Susceptibility of Plasmodium falciparum to a peroxidase-mediated oxygen-dependent microbicidal system.
作者信息
Malhotra K, Salmon D, Le Bras J, Vilde J L
机构信息
Institut National de la Santé et de la Recherche Médicale U 13, Paris, France.
出版信息
Infect Immun. 1988 Dec;56(12):3305-9. doi: 10.1128/iai.56.12.3305-3309.1988.
Abstract
The viability of Plasmodium falciparum in culture was assessed by [3H]hypoxanthine incorporation during 24 h of incubation with lactoperoxidase, glucose-glucose oxidase, hydrogen peroxide, halides, or thiocyanate, alone or in combination. Synergistic inhibition was produced by the following combinations: lactoperoxidase plus hydrogen peroxide, lactoperoxidase plus glucose-glucose oxidase, and lactoperoxidase plus hydrogen peroxide plus halides or thiocyanate. These inhibitory effects were reversed by catalase and glutathione. The presence of plasmodial crisis forms inside the erythrocytes suggests that the oxygen-dependent microbicidal system of phagocytes has a killing effect.
摘要
通过在与乳过氧化物酶、葡萄糖-葡萄糖氧化酶、过氧化氢、卤化物或硫氰酸盐单独或组合孵育24小时期间[3H]次黄嘌呤掺入来评估恶性疟原虫在培养物中的活力。以下组合产生协同抑制作用：乳过氧化物酶加过氧化氢、乳过氧化物酶加葡萄糖-葡萄糖氧化酶、以及乳过氧化物酶加过氧化氢加卤化物或硫氰酸盐。这些抑制作用可被过氧化氢酶和谷胱甘肽逆转。红细胞内疟原虫危机形式的存在表明吞噬细胞的氧依赖性杀菌系统具有杀伤作用。
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2
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3
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