氧化爆发的酶诱导产物对约氏疟原虫的杀伤作用。
Killing of Plasmodium yoelii by enzyme-induced products of the oxidative burst.
作者信息
Dockrell H M, Playfair J H
出版信息
Infect Immun. 1984 Feb;43(2):451-6. doi: 10.1128/iai.43.2.451-456.1984.
Abstract
The murine malaria parasite Plasmodium yoelii was killed in vitro when incubated with glucose and glucose oxidase, a system generating hydrogen peroxide, or with xanthine and xanthine oxidase, a system which produces the superoxide anion and subsequently other products of the oxidative burst. Catalase blocked the killing in both cases; superoxide dismutase and scavengers of hydroxyl radicals or singlet oxygen were ineffective in the xanthine oxidase system. Thus, hydrogen peroxide appears to be the main reactive oxygen species killing P. yoelii.
摘要
将鼠疟原虫约氏疟原虫与葡萄糖及葡萄糖氧化酶（一种能产生过氧化氢的系统）或与黄嘌呤及黄嘌呤氧化酶（一种能产生超氧阴离子并随后产生氧化爆发的其他产物的系统）一起孵育时，该寄生虫在体外被杀死。过氧化氢酶在这两种情况下均能阻止这种杀伤作用；超氧化物歧化酶以及羟基自由基或单线态氧的清除剂在黄嘌呤氧化酶系统中无效。因此，过氧化氢似乎是杀死约氏疟原虫的主要活性氧物质。
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