Charles Perkins Centre, School of Public Health, University of Sydney, Sydney, Australia.
Department of Epidemiology and Public Health, University College London, London, UK.
Br J Sports Med. 2017 May;51(10):818-823. doi: 10.1136/bjsports-2016-096723. Epub 2017 Jan 25.
Although certain types of sedentary behaviour have been linked to metabolic risk, prospective studies describing the links between sitting with incident diabetes are scarce and often do not account for baseline adiposity. We investigate the associations between context-specific sitting and incident diabetes in a cohort of mid-aged to older British civil servants.
Using data from the Whitehall II study (n=4811), Cox proportional hazards models (adjusted for age, sex, ethnicity, employment grade, smoking, alcohol intake, fruit and vegetable consumption, self-rated health, physical functioning, walking and moderate-to-vigorous physical activity, and body mass index (BMI)) were fitted to examine associations between total sitting and context-specific sitting time (work, television (TV), non-TV leisure time sitting at home) at phase 5 (1997-1999) and fasting glucose-defined incident diabetes up to 2011.
Total sitting (HR of the top compared with the bottom group: 1.26; 95% CI 1.00 to 1.62; p=0.01) and TV sitting (1.33; 95% CI 1.03 to 1.88; p=0.05) showed associations with incident diabetes; once BMI was included in the model these associations were attenuated for both total sitting (1.19; 95% CI 0.92 to 1.55; p=0.22) and TV sitting (1.31; 95% CI 0.96 to 1.76; p=0.14).
We found limited evidence linking sitting and incident diabetes over 13 years in this occupational cohort of civil servants.
尽管某些类型的久坐行为与代谢风险有关，但描述与新发糖尿病相关的坐姿的前瞻性研究很少，且这些研究通常未考虑基线肥胖。我们在一项中年至老年英国公务员队列中研究了特定情境下的坐姿与新发糖尿病之间的关联。
使用 Whitehall II 研究的数据（n=4811），使用 Cox 比例风险模型（调整年龄、性别、种族、职业级别、吸烟、饮酒量、水果和蔬菜摄入量、自我报告的健康状况、身体机能、步行和中等至剧烈体力活动以及体重指数（BMI）），检验了第 5 阶段（1997-1999 年）总坐姿和特定情境坐姿时间（工作、看电视（TV）、在家非 TV 休闲时间坐姿）与至 2011 年时空腹血糖定义的新发糖尿病之间的关联。
总坐姿（与最低组相比，最高组的 HR：1.26；95%CI 1.00 至 1.62；p=0.01）和 TV 坐姿（1.33；95%CI 1.03 至 1.88；p=0.05）与新发糖尿病有关；当 BMI 纳入模型后，总坐姿（1.19；95%CI 0.92 至 1.55；p=0.22）和 TV 坐姿（1.31；95%CI 0.96 至 1.76；p=0.14）的这些关联减弱。
我们在该公务员职业队列中发现，13 年来，坐姿与新发糖尿病之间的关联证据有限。
