Are all Sedentary Behaviors Equal? An Examination of Sedentary Behavior and Associations with Indicators of Disease Risk Factors in Women.

Sedentary behavior increases risk for non-communicable diseases; associations may differ within different contexts (e.g., leisure time, occupational). This study examined associations between different types of sedentary behavior and disease risk factors in women, using objectively measured accelerometer-derived sedentary data. A validation study ( = 20 women) classified sedentary behavior into four categories: lying down; sitting (non-active); sitting (active); standing. A cross-sectional study ( = 348 women) examined associations between these classifications and disease risk factors (body composition, metabolic, inflammatory, blood lipid variables). Participants spent an average of 7 h 42 min per day in sedentary behavior; 58% of that time was classified as non-active sitting and 26% as active sitting. Non-active sitting showed significant ( ≤ 0.001) positive correlations with BMI (r = 0.244), body fat percent ( = 0.216), body mass ( = 0.236), fat mass ( = 0.241), leptin ( = 0.237), and negative correlations with HDL-cholesterol ( = -0.117, = 0.031). Conversely, active sitting was significantly ( ≤ 0.001) negatively correlated with BMI ( = -0.300), body fat percent ( = -0.249), body mass ( = -0.305), fat mass ( = -0.320), leptin ( = -0.259), and positively correlated with HDL-cholesterol ( = 0.115, = 0.035). In summary, sedentary behavior can be stratified using objectively measured accelerometer-derived activity data. Subsequently, different types of sedentary behaviors may differentially influence disease risk factors. Public health initiatives should account for sedentary classifications when developing sedentary behavior recommendations.