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“蛇毒组学”中的策略旨在对毒液的组成、功能和免疫特性形成综合观点。

Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms.

作者信息

Lomonte Bruno, Calvete Juan J

机构信息

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, 11501 Costa Rica.

Structural and Functional Venomics Laboratory, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain.

出版信息

J Venom Anim Toxins Incl Trop Dis. 2017 Apr 28;23:26. doi: 10.1186/s40409-017-0117-8. eCollection 2017.

DOI:10.1186/s40409-017-0117-8
PMID:28465677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5408369/
Abstract

This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achieving a more comprehensive knowledge on the compositional, toxic, and immunological characteristics of venoms. Some recent developments in this field are summarized, highlighting how strategies have evolved from the mere cataloguing of venom components (proteomics/venomics), to a broader exploration of their immunological (antivenomics) and functional (toxicovenomics) characteristics. Altogether, the combination of these complementary strategies is helping to build a wider, more integrative view of the life-threatening protein cocktails produced by venomous snakes, responsible for thousands of deaths every year.

摘要

这项工作对蛇毒蛋白质组学分析不断发展的策略进行了总体概述，并讨论了如何通过多种实验方法将这些策略结合起来，以期更全面地了解蛇毒的组成、毒性和免疫特性。本文总结了该领域的一些最新进展，强调了策略是如何从单纯的毒液成分编目（蛋白质组学/毒液组学），发展到对其免疫（抗蛇毒血清组学）和功能（毒理蛋白质组学）特性进行更广泛的探索。总之，这些互补策略的结合有助于构建一个更广泛、更综合的视角，来认识由毒蛇产生的、每年导致数千人死亡的致命蛋白质混合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/acbfb520647f/40409_2017_117_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/71f54e3bcfd2/40409_2017_117_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/45e3269e184b/40409_2017_117_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/d9d44cc0d961/40409_2017_117_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/acbfb520647f/40409_2017_117_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/71f54e3bcfd2/40409_2017_117_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/45e3269e184b/40409_2017_117_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/d9d44cc0d961/40409_2017_117_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/82b4/5408369/acbfb520647f/40409_2017_117_Fig4_HTML.jpg

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