Sorisky Alexander
Chronic Disease Program, Ottawa Hospital Research Institute, and Departments of Medicine and of Biochemistry, Microbiology & Immunology, University of Ottawa, Ottawa, ON K1H 8L6, Canada.
Int J Mol Sci. 2017 Apr 29;18(5):944. doi: 10.3390/ijms18050944.
White adipocytes release adipokines that influence metabolic and vascular health. Hypertrophic obesity is associated with adipose tissue malfunctioning, leading to inflammation and insulin resistance. When pancreatic islet β cells can no longer compensate, the blood glucose concentration rises (hyperglycemia), resulting in type 2 diabetes. Hyperglycaemia may further aggravate adipose cell dysfunction in ~90% of patients with type 2 diabetes who are obese or overweight. This review will focus on the effects of high glucose levels on human adipose cells and the regulation of adipokines.
白色脂肪细胞释放影响代谢和血管健康的脂肪因子。肥大性肥胖与脂肪组织功能失调有关，会导致炎症和胰岛素抵抗。当胰岛β细胞无法再进行代偿时，血糖浓度就会升高（高血糖症），从而导致2型糖尿病。在约90%肥胖或超重的2型糖尿病患者中，高血糖症可能会进一步加重脂肪细胞功能障碍。本综述将聚焦于高糖水平对人体脂肪细胞的影响以及脂肪因子的调节。
