Picu Ariana, Petcu Laura, Ştefan Simona, Mitu Manuela, Lixandru Daniela, Ionescu-Tîrgovişte Constantin, Pîrcălăbioru Grațiela Grădișteanu, Ciulu-Costinescu Felicia, Bubulica Maria-Viorica, Chifiriuc Mariana Carmen
NIDNMD "Prof. N.C. Paulescu", 2th district, Bucharest 020042, Romania.
Faculty of Biology, University of Bucharest, 5th district, Bucharest 050095, Romania.
Molecules. 2017 May 1;22(5):714. doi: 10.3390/molecules22050714.
Type 2 diabetes mellitus (T2DM) is strongly associated with obesity. The adipose tissue secretes bioactive adipokines leading to low grade inflammation, amplified by oxidative stress, which promotes the formation of advanced glycation end products and eventually leads to dyslipidemia and vascular complications. The aim of this study was to correlate anthropometric, biochemical and oxidative stress parameters in newly diagnosed (ND) T2DM patients and to investigate the role of oxidative stress in T2DM associated with obesity. A group of 115 ND- T2DM patients was compared to a group of 32 healthy subjects in terms of clinical, anthropometric, biochemical and oxidative stress parameters. ND-T2DM patients had significantly lower adiponectin, glutathione (GSH) and gluthatione peroxidase (GPx) and elevated insulin, proinsulin, HOMA-IR index, proinsulin/insulin (P/I) and proinsulin/adiponectin (P/A) ratio, fructosamine, and total oxidant status (TOS). The total body fat mass was positively correlated with total oxidant status (TOS). Positive correlations were found between TOS and glycated hemoglobin (HbA1c), and between TOS and glycaemia. Negative correlations were identified between: GPx and glycaemia, GPx and HbA1c, and also between GSH and fructosamine. The total antioxidant status was negatively correlated with the respiratory burst. The identified correlations suggest the existence of a complex interplay between diabetes, obesity and oxidative stress.
2型糖尿病（T2DM）与肥胖密切相关。脂肪组织分泌生物活性脂肪因子，导致低度炎症，氧化应激会加剧这种炎症，氧化应激会促进晚期糖基化终产物的形成，并最终导致血脂异常和血管并发症。本研究的目的是关联新诊断（ND）的T2DM患者的人体测量学、生化和氧化应激参数，并研究氧化应激在与肥胖相关的T2DM中的作用。将一组115名ND-T2DM患者与一组32名健康受试者在临床、人体测量学、生化和氧化应激参数方面进行比较。ND-T2DM患者的脂联素、谷胱甘肽（GSH）和谷胱甘肽过氧化物酶（GPx）显著降低，而胰岛素、胰岛素原、HOMA-IR指数、胰岛素原/胰岛素（P/I）和胰岛素原/脂联素（P/A）比值、果糖胺和总氧化剂状态（TOS）升高。全身脂肪量与总氧化剂状态（TOS）呈正相关。发现TOS与糖化血红蛋白（HbA1c）之间以及TOS与血糖之间呈正相关。在以下各项之间发现负相关：GPx与血糖、GPx与HbA1c，以及GSH与果糖胺之间。总抗氧化剂状态与呼吸爆发呈负相关。所确定的相关性表明糖尿病、肥胖和氧化应激之间存在复杂的相互作用。
