Friend小鼠白血病病毒整合到一个红白血病细胞系中p53癌基因的两个等位基因中。
Integration of Friend murine leukemia virus into both alleles of the p53 oncogene in an erythroleukemic cell line.
作者信息
Hicks G G, Mowat M
机构信息
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
出版信息
J Virol. 1988 Dec;62(12):4752-5. doi: 10.1128/JVI.62.12.4752-4755.1988.
Abstract
The Friend virus-transformed erythroleukemic cell line DP16-9B4 has undergone a complex rearrangement of the p53 oncogene and lacks any detectable expression of the p53 protein. We report here characterization of both p53 alleles in this cell line and identify independent integrations of Friend murine leukemia virus sequences into the coding region of both alleles.
摘要
Friend病毒转化的红白血病细胞系DP16-9B4经历了p53癌基因的复杂重排，且未检测到p53蛋白的任何表达。我们在此报告该细胞系中两个p53等位基因的特征，并确定Friend鼠白血病病毒序列独立整合到两个等位基因的编码区域。
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