Suhag Virender, Sunita B S, Vats Pankaj, Sarin Arti, Singh A K, Jain Mayuri
Department of Radiotherapy, Army Hospital RR, Delhi, India.
Department of Pathology, Army Hospital RR, Delhi, India.
Indian J Med Paediatr Oncol. 2017 Jan-Mar;38(1):28-32. doi: 10.4103/0971-5851.203497.
Pediatric tumors are a heterogeneous group of malignant conditions requiring multimodal treatment, and management of such cases is at time challenging. We present the clinical profile of pediatric cancer patients who received radiation, either alone or as adjuvant to surgery and chemotherapy; in prophylactic, radical or palliative clinical setting.
This study was envisaged to review our experience of pediatric oncology cases, their clinical and morphological profile, dosage schedule of radiotherapy, and the therapy induced complications.
This was a retrospective, observational study carried out in an apex tertiary care cancer institute of government set-up in a developing country.
The treatment charts and clinical summary of patients who had received radiation over the last 5 years period were retrieved and perused. Various clinical and pathological parameters were studied and inferences drawn.
A total of 50 patients got radiation over 5 year study-period, including 37 male and 13 female patients. The commonest age group of presentation was 8-12 years followed by 13-16 years. The mean age of presentation was 9.3 years. The most common diagnosis was hematological malignancies followed by CNS tumors with 21 and 13 patients respectively. Overall the most common indication of RT was in adjuvant setting after surgery as the definitive management, where 24 patients were irradiated; and the next common indication was prophylactic cranial irradiation in 14 patients of childhood leukemias. 10 patients tolerated treatment with Grade 1 site-specific or systemic toxicities while 7 patients developed Grade 2 and more systemic toxicities. 9 patients received craniospinal irradiation, common indications being medulloblastoma and Atypical teratoma rhabdoid tumor (ATRT). 3 patients received concurrent chemotherapy with weekly Inj Vincristine. 17 patients required sedation or short general anaesthesia for radiation planning and execution.
External beam Radiotherapy constitutes an important component of management of pediatric cancers. One should be judicious in Radiotherapy planning, execution and monitoring acute and delayed toxicities.
儿科肿瘤是一组需要多模式治疗的异质性恶性疾病，此类病例的管理有时具有挑战性。我们介绍了接受放疗的儿科癌症患者的临床概况，放疗方式包括单独放疗，或作为手术和化疗的辅助治疗；应用于预防性、根治性或姑息性临床情况。
本研究旨在回顾我们在儿科肿瘤病例方面的经验、患者的临床和形态学特征、放疗剂量方案以及治疗引起的并发症。
这是一项在发展中国家政府设立的顶级三级癌症护理机构中进行的回顾性观察研究。
检索并查阅了过去5年期间接受放疗患者的治疗图表和临床总结。对各种临床和病理参数进行了研究并得出推论。
在5年的研究期间，共有50例患者接受了放疗，其中男性37例，女性13例。最常见的就诊年龄组为8至12岁，其次是13至16岁。就诊时的平均年龄为9.3岁。最常见的诊断是血液系统恶性肿瘤，其次是中枢神经系统肿瘤，分别有21例和13例患者。总体而言，放疗最常见的适应证是作为手术后的辅助治疗作为确定性治疗，有24例患者接受了放疗；其次常见的适应证是对14例儿童白血病患者进行预防性颅脑照射。10例患者耐受1级部位特异性或全身毒性的治疗，而7例患者出现2级及以上全身毒性。9例患者接受了全脑全脊髓照射，常见适应证为髓母细胞瘤和非典型畸胎瘤横纹肌样肿瘤（ATRT）。3例患者接受了每周静脉注射长春新碱的同步化疗。17例患者在放疗计划和实施过程中需要镇静或短暂全身麻醉。
外照射放疗是儿科癌症管理的重要组成部分。在放疗计划、实施以及监测急性和迟发性毒性方面应谨慎行事。
