高山槐黄酮抑制透明细胞肾细胞癌的肿瘤生长和转移。
Alpinumisoflavone suppresses tumour growth and metastasis of clear-cell renal cell carcinoma.
作者信息
Wang Tingting, Jiang Yuhua, Chu Lei, Wu Tianhui, You Jie
机构信息
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of MedicineShanghai 200011, China.
Tumor Hospital of QingdaoShandong 266042, China.
出版信息
Am J Cancer Res. 2017 Apr 1;7(4):999-1015. eCollection 2017.
Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. The present study is aimed to investigate the role of alpinumisoflavone (AIF), a naturally occurring flavonoid compound, in ccRCC and the underlying mechanism. In this study, miR-101 has been identified as a novel therapeutic target, which exerts anti-tumor effect on ccRCC by directly targeting RLIP76. Moreover, our results showed that AIF was able to increase the expression of miR-101 by suppressing Akt signalling. Our findings in this study provided experimental evidence that AIF has the potential to be used as an agent in the treatment of ccRCC.
摘要
透明细胞肾细胞癌（ccRCC）是最常见的肾癌类型。本研究旨在探讨天然存在的黄酮类化合物高山槐黄素（AIF）在ccRCC中的作用及其潜在机制。在本研究中，miR-101已被确定为一个新的治疗靶点，它通过直接靶向RLIP76对ccRCC发挥抗肿瘤作用。此外，我们的结果表明，AIF能够通过抑制Akt信号传导来增加miR-101的表达。我们在本研究中的发现提供了实验证据，表明AIF有潜力用作治疗ccRCC的药物。
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