Johansen K, Hansen J M, Perrild H, Skovsted L, Kampmann J P
Acta Med Scand Suppl. 1979;624:25-30. doi: 10.1111/j.0954-6820.1979.tb00714.x.
We studied the effect of suppressive therapy with graded doses of thyroxine (T4) on serum levels of T4, 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine [rT3] in patients with diffuse, nontoxic goiter. For comparison and in order to elucidate the degree of suppression of the pituitary thyroid axis by T3 the effect of suppressive therapy with T3 was studied in the same type of patients. We found that T4 in serum rose significantly to a constant level during T4 treatment (0.10, 0.15 and 0.20 mg/day). Dose-related rises in T4 were only seen after 3 months of treatment. T3 and rT3 only changed minimally. The T4/T3 ratio rose to a constant level during the initial 3 months of treatment. T3/rT3 ratio remained unchanged. No dose-related differences in T4/T3 and T3/rT3 ratio were observed. Treatment with T3 in doses of 0.06 mg per day caused a significant but slow fall in T4 and rT3 to hypothroid levels while T3 only rose slightly. The T4/T3 ratio dropped significantly during T3 therapy.
我们研究了不同剂量甲状腺素（T4）抑制疗法对弥漫性非毒性甲状腺肿患者血清T4、3,5,3'-三碘甲状腺原氨酸（T3）和3,3',5'-三碘甲状腺原氨酸[rT3]水平的影响。为作比较并阐明T3对垂体-甲状腺轴的抑制程度，我们在同一类患者中研究了T3抑制疗法的效果。我们发现，在T4治疗期间（0.10、0.15和0.20毫克/天），血清T4显著升高并达到稳定水平。仅在治疗3个月后才出现与剂量相关的T4升高。T3和rT3仅有微小变化。在治疗的最初3个月内，T4/T3比值升至稳定水平。T3/rT3比值保持不变。未观察到T4/T3和T3/rT3比值存在剂量相关差异。每天0.06毫克剂量的T3治疗导致T4和rT3显著但缓慢下降至甲状腺功能减退水平，而T3仅略有升高。在T3治疗期间，T4/T3比值显著下降。
