Mahmood Shakil, Rahman Matiur, Biswas Subrata Kumar, Saqueeb Shaikh Nazmus, Zaman Shiblee, Manirujjaman M, Perveen Rasheda, Ali Nurshad
Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.
Department of Biochemistry and Molecular Biology, Gonoshasthaya Samaj Vittik Medical College and Hospital, Gono University, Savar, Dhaka 1344, Bangladesh.
Biomed Res Int. 2017;2017:4105375. doi: 10.1155/2017/4105375. Epub 2017 Apr 3.
Despite the abundant sunlight, vitamin D deficiency is prevalent in South Asian countries including Bangladesh. Information on vitamin D level is insufficient in adults particularly in female garment workers in Bangladesh. This study was designed to evaluate the status of vitamin D, parathormone (PTH), calcium, and alkaline phosphatase (ALP) among the female garment workers in Bangladesh. Blood samples were collected from female garment workers ( = 40, case group) and general female workers ( = 40, control group) in Dhaka. Serum vitamin D, PTH, calcium, and ALP were measured by chemiluminescence microparticle immunoassay. The mean level of vitamin D was significantly ( < 0.001) lower in case (14.2 ± 2.6 ng/mL) than in the control (22.4 ± 2.4 ng/mL) group. No significant difference was found at mean of PTH and calcium between case (33.9 ± 17.2 pg/mL; 9.1 ± 0.6 mg/dL, resp.) and control (35.9 ± 16.3 pg/mL; 9.3 ± 0.6 mg/dL, resp.) group. The mean ALP in case (117.2 ± 14.4 U/L) group was significantly ( < 0.001) higher than the control group (80.5 ± 30.6 U/L). Overall, PTH level did not show significant correlation with vitamin D. However, calcium and ALP levels showed a significant positive ( < 0.05) and negative ( < 0.001) correlation with vitamin D, respectively. This study indicates a high prevalence of vitamin D deficiency in the female garment workers in Bangladesh.
尽管阳光充足，但包括孟加拉国在内的南亚国家维生素D缺乏症却很普遍。在孟加拉国，成年人尤其是女性服装工人中，关于维生素D水平的信息不足。本研究旨在评估孟加拉国女性服装工人的维生素D、甲状旁腺激素（PTH）、钙和碱性磷酸酶（ALP）的状况。从达卡的女性服装工人（n = 40，病例组）和普通女工（n = 40，对照组）中采集血样。采用化学发光微粒子免疫分析法测定血清维生素D、PTH、钙和ALP。病例组（14.2±2.6 ng/mL）的维生素D平均水平显著低于对照组（22.4±2.4 ng/mL）（P<0.001）。病例组（分别为33.9±17.2 pg/mL；9.1±0.6 mg/dL）和对照组（分别为35.9±16.3 pg/mL；9.3±0.6 mg/dL）的PTH和钙平均值无显著差异。病例组（117.2±14.4 U/L）的ALP平均水平显著高于对照组（80.5±30.6 U/L）（P<0.001）。总体而言，PTH水平与维生素D无显著相关性。然而，钙和ALP水平与维生素D分别呈显著正相关（P<0.05）和负相关（P<0.001）。本研究表明孟加拉国女性服装工人中维生素D缺乏症的患病率很高。
