循环肿瘤细胞与凝血——综述

Circulating tumor cells and coagulation-Minireview.

作者信息

Bystricky Branislav, Reuben James M, Mego Michal

机构信息

2(nd) Department of Medical Oncology, Faculty of Medicine, Comenius University and National Cancer Institute, Bratislava, Slovakia; Department of Oncology, Trencin Hospital, Trencin, Slovakia.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Crit Rev Oncol Hematol. 2017 Jun;114:33-42. doi: 10.1016/j.critrevonc.2017.04.003. Epub 2017 Apr 6.

DOI:10.1016/j.critrevonc.2017.04.003

PMID:28477745

Abstract

Venous thromboembolic events in cancer patients signify poor prognosis. Prophylactic treatment of ambulatory patients with anticoagulants is currently not recommended. Circulating tumor cells, either directly or indirectly, are associated with prothrombotic state. In this review, we discuss various interactions of circulating tumor cells with the coagulation pathway in cancer patient.

摘要

癌症患者发生静脉血栓栓塞事件预示着预后不良。目前不建议对非卧床患者使用抗凝剂进行预防性治疗。循环肿瘤细胞直接或间接与血栓前状态相关。在本综述中，我们讨论了癌症患者循环肿瘤细胞与凝血途径的各种相互作用。