Ing B L, Gupta D K, Nawab Z M, Zhou F Q, Rahman M A, Daugirdas J T
Department of Medicine, Veterans Administration Hospital, Hines, Illinois.
Int J Artif Organs. 1988 Sep;11(5):351-4.
The pH of conventional peritoneal dialysis solution is normally in the range of 5.0 to 5.5, because acid has been added during the manufacturing process to prevent caramelization of dextrose during sterilization. We studied the effects of normalizing the pH of conventional peritoneal dialysis solution on superoxide production by normal human neutrophils. At a pH of 6.0, superoxide generation was 4.07 +/- 2.56 (SD) nanomoles per million cells. With normalization of pH to 7.4, superoxide production was 19.3 +/- 7.3 (p less than 0.001). The results suggest that the unphysiologic acidity of conventional peritoneal dialysis solution has deleterious consequences on neutrophil superoxide formation.
传统腹膜透析液的pH值通常在5.0至5.5范围内，因为在制造过程中添加了酸以防止葡萄糖在灭菌过程中焦糖化。我们研究了将传统腹膜透析液的pH值正常化对正常人中性粒细胞产生超氧化物的影响。在pH值为6.0时，超氧化物生成量为每百万细胞4.07±2.56（标准差）纳摩尔。随着pH值正常化为7.4，超氧化物生成量为19.3±7.3（p<0.001）。结果表明，传统腹膜透析液的非生理酸度对中性粒细胞超氧化物形成有有害影响。
