Tase T, Sato S, Wada Y, Yajima A, Okagaki T
Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1988 Sep;156(1):47-53. doi: 10.1620/tjem.156.47.
To identify whether the incidence of human papillomavirus (HPV) type 18 DNA in adenocarcinoma and adenosquamous carcinoma is attributable to the histological types or geographical differences, the presence of HPV-16 and HPV-18 DNA in carcinoma of the uterine cervix from Japan were studied by in situ hybridization using tritium labeled HPV DNA probes. HPV-18 DNA was detected in 5 of 11 cases (45%) of adenocarcinoma, one case of adenocarcinoma in situ and 2 of 3 cases of adenosquamous carcinoma. In contrast, HPV-16 DNA was detected in 2 of 11 cases (18%) of adenocarcinoma, and 3 of 7 cases (43%) of squamous cell carcinoma. Compared with our previous results (Tase et al. 1988), the present results imply that the prevalence of HPV-18 DNA in carcinoma of the uterine cervix is attributable rather to the histological differences than to the geographical differences.
为了确定18型人乳头瘤病毒（HPV）DNA在腺癌和腺鳞癌中的发生率是归因于组织学类型还是地理差异，我们使用氚标记的HPV DNA探针，通过原位杂交研究了日本子宫颈癌中HPV - 16和HPV - 18 DNA的存在情况。在11例腺癌病例中有5例（45%）、1例原位腺癌以及3例腺鳞癌病例中的2例检测到了HPV - 18 DNA。相比之下，在11例腺癌病例中有2例（18%）检测到HPV - 16 DNA，在7例鳞状细胞癌病例中有3例（43%）检测到HPV - 16 DNA。与我们之前的结果（Tase等人，1988年）相比，目前的结果表明子宫颈癌中HPV - 18 DNA的流行率更多地归因于组织学差异而非地理差异。
