Mii Y, Miyauchi Y, Kambara K, Hohnoki K, Masuhara K
Department of Orthopedic Surgery, Nara Medical University, Japan.
Ultrastruct Pathol. 1988 Sep-Oct;12(5):537-46. doi: 10.3109/01913128809032238.
Crystalloid structures were frequently observed in the cytoplasm of the tumor cells of a malignant fibrous histiocytoma arising in the left leg of a 71-year-old female. These structures were located in the cytoplasm of the fibroblastlike and histiocyte-like tumor cells. The structures consisted of an aggregate of dense granules without unit membrane. Neither glycoproteins nor polysaccharides were detected in these structures on sections stained with chromic acid-phosphotungstic acid or periodic acid-thiocarbohydrazide-silver proteinate. On sections from acrylate-embedded specimens, the structures were easily digested by trypsin and protease but were not sensitive to RNase. Although the significance and origin of these structures remain obscure, the results indicate that the crystalloid structures in the present study are mainly composed of proteinaceous substance.
在一名71岁女性左腿发生的恶性纤维组织细胞瘤的肿瘤细胞胞质中，经常观察到晶体样结构。这些结构位于成纤维细胞样和组织细胞样肿瘤细胞的胞质中。这些结构由无单位膜的致密颗粒聚集体组成。在用铬酸 - 磷钨酸或高碘酸 - 硫代碳酰肼 - 银蛋白染色的切片上，这些结构中未检测到糖蛋白或多糖。在丙烯酸酯包埋标本的切片上，这些结构很容易被胰蛋白酶和蛋白酶消化，但对核糖核酸酶不敏感。尽管这些结构的意义和起源仍不清楚，但结果表明本研究中的晶体样结构主要由蛋白质物质组成。
