McMillan M D, Smillie A C, Ferguson J W
J Oral Pathol. 1986 May;15(5):255-60. doi: 10.1111/j.1600-0714.1986.tb00618.x.
A 42-year-old female presented with a 2.5 cm symptomless swelling on the left lateral surface of the tongue. Histologically, there were large, often pleomorphic, fibroblast-like and histiocyte-like cells, multinucleate giant cells and cells of variable morphology. Many of the cells had abundant vesicular cytoplasm. There were also aggregations of neutrophilic or eosinophilic leukocytes, or both. The cells in some areas formed a fascicular or storiform pattern, or both. Ultrastructurally, the vesicular appearance was due mostly to markedly dilated endoplasmic reticulum, but many of the neoplastic cells contained some lipid. There were some myofibroblasts and a few xanthofibroblasts. The cells of variable morphology had many of the ultrastructural features of the fibroblast and histiocyte-like cells. There were also some small undifferentiated cells with minimal cytoplasm. These ultrastructural features confirmed the histological diagnosis of malignant fibrous histiocytoma.
一名42岁女性，舌左侧面出现一个2.5厘米无症状肿物。组织学上，可见大量通常呈多形性的成纤维细胞样和组织细胞样细胞、多核巨细胞以及形态各异的细胞。许多细胞具有丰富的泡状细胞质。也有嗜中性或嗜酸性白细胞聚集，或两者皆有。某些区域的细胞形成束状或车辐状结构，或两者兼具。超微结构上，泡状外观主要归因于内质网明显扩张，但许多肿瘤细胞含有一些脂质。有一些肌成纤维细胞和少量黄色纤维母细胞。形态各异的细胞具有许多成纤维细胞样和组织细胞样细胞的超微结构特征。也有一些细胞质极少的小未分化细胞。这些超微结构特征证实了恶性纤维组织细胞瘤的组织学诊断。
