Topilko A, Zakrzewski A, Pichard E, Viron A
Ultrastruct Pathol. 1984;6(2-3):221-8. doi: 10.3109/01913128409018576.
Electron-dense round granules (ING) were found in the nuclei of fibroblastic cells of all the tumors examined by us (6 cases) and diagnosed clinically and histologically as nasopharyngeal angiofibroma (NPAF). The ING were consistently associated with this tumor and can be regarded as pathognomonic of NPAF. We studied at the ultrastructural level the composition of these particles using various cytochemical techniques. Enzymatic digestions carried out on thin sections as well as staining methods preferential or specific for nucleoproteins have revealed that ING represent tightly bound RNA-protein complexes and do not contain DNA. There are no data available that the ING takes part in the metabolism of NPAF fibroblastic cells.
在我们检查的所有肿瘤（6例）的成纤维细胞细胞核中发现了电子致密的圆形颗粒（ING），这些肿瘤经临床和组织学诊断为鼻咽血管纤维瘤（NPAF）。ING始终与这种肿瘤相关，可被视为NPAF的特征性表现。我们使用各种细胞化学技术在超微结构水平上研究了这些颗粒的组成。对超薄切片进行的酶消化以及对核蛋白具有优先性或特异性的染色方法表明，ING代表紧密结合的RNA-蛋白质复合物，不含DNA。目前尚无数据表明ING参与NPAF成纤维细胞的代谢。
