Zhou Yu-Jie, Zhao Dan-Dan, Liu Huidi, Chen Hao-Ting, Li Jia-Jing, Mu Xiao-Qin, Liu Zheng, Li Xia, Tang Le, Zhao Zhan-Yi, Wu Ji-Heng, Cai Yu-Xuan, Huang Ya-Zhuo, Wang Peng-Ge, Jia Yi-Yue, Liang Pei-Qiang, Peng Xue, Chen Si-Yu, Yue Zhi-Lin, Yuan Xin-Yuan, Lu Tammy, Yao Bing-Qing, Li Yong-Guo, Liu Gui-Rong, Liu Shu-Lin
Systemomics Center, College of Pharmacy, and Genomics Research Center, State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Harbin Medical University, Harbin, China.
HMU-UCFM Centre for Infection and Genomics, Harbin Medical University, Harbin, China.
Oncotarget. 2017 Jul 25;8(30):49574-49591. doi: 10.18632/oncotarget.17319.
Cancer as a large group of complex diseases is believed to result from the interactions of numerous genetic and environmental factors but may develop in people without any known genetic or environmental risks, suggesting the existence of other powerful factors to influence the carcinogenesis process. Much attention has been focused recently on particular members of the intestinal microbiota for their potential roles in promoting carcinogenesis. Here we report the identification and characterization of intestinal bacteria that exhibited potent anti-malignancy activities on a broad range of solid cancers and leukemia. We collected fecal specimens from healthy individuals of different age groups (preschool children and university students), inspected their effects on cancer cells, and obtained bacteria with potent anti-malignancy activities. The bacteria mostly belonged to Actinobacteria but also included lineages of other phyla such as Proteobacteria and Firmicutes. In animal cancer models, sterile culture supernatant from the bacteria highly effectively inhibited tumor growth. Remarkably, intra-tumor administration of the bacterial products prevented metastasis and even cleared cancer cells at remote locations from the tumor site. This work demonstrates the prevalent existence of potent malignancy-killers in the human intestinal microbiota, which may routinely clear malignant cells from the body before they form cancers.
癌症作为一大类复杂疾病，被认为是由众多遗传和环境因素相互作用导致的，但也可能在没有任何已知遗传或环境风险的人群中发生，这表明存在其他强大因素影响致癌过程。最近，肠道微生物群的特定成员因其在促进致癌作用中的潜在作用而备受关注。在此，我们报告了对在多种实体癌和白血病中表现出强大抗癌活性的肠道细菌的鉴定和特征描述。我们从不同年龄组（学龄前儿童和大学生）的健康个体中收集粪便样本，检测它们对癌细胞的影响，并获得了具有强大抗癌活性的细菌。这些细菌大多属于放线菌门，但也包括其他门的谱系，如变形菌门和厚壁菌门。在动物癌症模型中，这些细菌的无菌培养上清液能高效抑制肿瘤生长。值得注意的是，肿瘤内注射细菌产物可防止转移，甚至清除远离肿瘤部位的癌细胞。这项研究表明，人类肠道微生物群中普遍存在强大的抗癌物质，它们可能在恶性细胞形成癌症之前就常规性地将其从体内清除。
