Draganovic Dragica, Lucic Nenad, Jojic Dragica, Milicevic Snjezana
Clinic of Gynecology and Obstetrics, University Clinical Centre of the Republic of Srpska, Banjaluka, Bosnia and Herzegovina.
Clinic of Pediatric, University Clinical Centre of the Republic of Srpska, Banjaluka, Bosnia and Herzegovina.
Acta Inform Med. 2017 Mar;25(1):19-23. doi: 10.5455/aim.2017.25.19-23.
Pregnancy induced hypertension (PIH), especially preeclampsia, is a state of extremely increased oxidative stress (OS), due to decrease of antioxidant capacity in comparison to normotensive pregnant women. The consequences of increased state of oxidative stress with hypertension disorder in pregnancy are disorder of placental blood flow, intrauterine hypoxia of the fetus and disturbance in transfer of O2 manifested as pathological ultrasound (US) parameters (amount of amniotic fluid and biophysical profile of fetus) and cardiotocography parameters (CTG).
The aim of this research is to analyze correlation of TBARS oxidative stress markers with ultrasound parameters of pregnancy course and cardiotocography parameters in pregnant women with PIH.
Research has been performed at the Clinic of Gynecology and Obstetrics, University Clinical Centre of the Republic of Srpska. It covered 200 pregnant women, 100 of them with PIH and 100 healthy pregnant women, at gestational age from 28 to 40 weeks. All pregnant women were analyzed for US parameters of pregnancy course and CTG records as well as oxidative stress biomarker, values of Thiobarbituric Acid (TBARS).
Pregnant women with PIH had high statistical significant (pre)pathological CTG records and US- biophysical profile, less amount of amniotic fluid and delivered in lower gestation compared to healthy pregnant women. TBARS high values are statistical high significant frequent with pregnant women with PIH, who had pathological and pre-pathological biophysical profile and CTG records, as well as with US less amount of amniotic fluid (p<0.01). The highest TBARS values were presented with PIH pregnant women and US of less amount of amniotic fluid 42.3 µmol.
There is statistical strong connection between TBARS values, being used as oxidative stress markers, and diagnostic methods used in PIH diagnostics, ultrasound (amount of amniotic fluid, fetus biophysical profile) and cardiotocography recording. TBARS could also be significant in clinical application for assessment of pregnant women with PIH in order to make decisions on pregnancy termination period.
妊娠高血压疾病（PIH），尤其是子痫前期，是一种氧化应激（OS）极度增加的状态，这是由于与血压正常的孕妇相比抗氧化能力下降所致。妊娠高血压疾病中氧化应激增加状态的后果包括胎盘血流紊乱、胎儿宫内缺氧以及氧气转运障碍，表现为病理超声（US）参数（羊水含量和胎儿生物物理评分）和胎心监护参数（CTG）异常。
本研究的目的是分析丙二醛（TBARS）氧化应激标志物与PIH孕妇妊娠过程的超声参数和胎心监护参数之间的相关性。
研究在塞尔维亚共和国大学临床中心妇产科诊所进行。研究对象为200名孕妇，其中100名患有PIH，100名健康孕妇，孕周为28至40周。所有孕妇均接受了妊娠过程的超声参数和CTG记录分析以及氧化应激生物标志物硫代巴比妥酸（TBARS）值的检测。
与健康孕妇相比，患有PIH的孕妇有高度统计学意义的（前）病理CTG记录和超声生物物理评分，羊水含量较少，且分娩孕周较小。TBARS高值在患有PIH且有病理和前病理生物物理评分及CTG记录的孕妇以及羊水含量较少的超声检查中统计学上高度频繁出现（p<0.01）。PIH孕妇且羊水含量较少时TBARS值最高，为42.3微摩尔。
用作氧化应激标志物的TBARS值与PIH诊断中使用的诊断方法（超声（羊水含量、胎儿生物物理评分）和胎心监护记录）之间存在统计学上的强关联。TBARS在临床应用中对于评估PIH孕妇以决定终止妊娠时机方面也可能具有重要意义。
