Lee Eunice Y, Lin Jue, Noth Elizabeth M, Hammond S Katharine, Nadeau Kari C, Eisen Ellen A, Balmes John R
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley (Ms Lee, Dr Noth, Dr Hammond, Dr Eisen, Dr Balmes); Division of Immunology and Allergy, School of Medicine, Stanford University, Stanford (Dr Nadeau); Department of Biochemistry and Biophysics (Dr Lin); Division of Occupational and Environmental Medicine, School of Medicine (Dr Balmes), University of California, San Francisco, San Francisco, California.
J Occup Environ Med. 2017 May;59(5):446-452. doi: 10.1097/JOM.0000000000000996.
The main objective of this pilot study was to gather preliminary information about how telomere length (TL) varies in relation to exposure to polycyclic aromatic hydrocarbons (PAHs) in children living in a highly polluted city.
We conducted a cross-sectional study of children living in Fresno, California (n = 14). Subjects with and without asthma were selected based on their annual average PAH level in the 12-months prior to their blood draw. We measured relative telomere length from peripheral blood mononuclear cells (PBMC).
We found an inverse linear relationship between average PAH level and TL (R = 0.69), as well as between age and TL (R = 0.21). Asthmatics had shorter mean telomere length than non-asthmatics (TLasthmatic = 1.13, TLnon-asthmatic = 1.29).
These preliminary findings suggest that exposure to ambient PAH may play a role in telomere shortening.Become familiar with previous evidence suggesting that telomere length may be a biomarker of air pollution-induced cytotoxicity.Summarize the new findings on the association between polycyclic aromatic hydrocarbon (PAH) exposure and telomere length in adolescents, including those with asthma.Discuss the implications for recommendations and policies to mitigate the health and respiratory effects of traffic-related air pollution.
这项初步研究的主要目的是收集关于生活在高污染城市的儿童端粒长度（TL）如何随多环芳烃（PAH）暴露而变化的初步信息。
我们对居住在加利福尼亚州弗雷斯诺的儿童进行了一项横断面研究（n = 14）。根据采血前12个月的年度平均PAH水平选择有或无哮喘的受试者。我们测量了外周血单个核细胞（PBMC）的相对端粒长度。
我们发现平均PAH水平与TL之间存在负线性关系（R = 0.69），年龄与TL之间也存在负线性关系（R = 0.21）。哮喘患者的平均端粒长度比非哮喘患者短（哮喘患者TL = 1.13，非哮喘患者TL = 1.29）。
这些初步发现表明，暴露于环境PAH可能在端粒缩短中起作用。熟悉先前的证据，即端粒长度可能是空气污染诱导细胞毒性的生物标志物。总结关于青少年多环芳烃（PAH）暴露与端粒长度之间关联的新发现，包括患有哮喘的青少年。讨论对减轻交通相关空气污染对健康和呼吸影响的建议和政策的影响。
