用于骨靶向药物递送的纳米材料的开发。
Development of nanomaterials for bone-targeted drug delivery.
机构信息
Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, Boston, MA 02139, USA; Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Orthopaedic Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women's Hospital, Boston, MA 02139, USA; Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
出版信息
Drug Discov Today. 2017 Sep;22(9):1336-1350. doi: 10.1016/j.drudis.2017.04.021. Epub 2017 May 6.
Bone is one of the major organs of the human body; it supports and protects other organs, produces blood cells, stores minerals, and regulates hormones. Therefore, disorders in bone can cause serious morbidity, complications, or mortality of patients. However, despite the significant occurrence of bone diseases, such as osteoarthritis (OA), osteoporosis (OP), non-union bone defects, bone cancer, and myeloma-related bone disease, their effective treatments remain a challenge. In this review, we highlight recent progress in the development of nanotechnology-based drug delivery for bone treatment, based on its improved delivery efficiency and safety. We summarize the most commonly used nanomaterials for bone drug delivery. We then discuss the targeting strategies of these nanomaterials to the diseased sites of bone tissue. We also highlight nanotechnology-based drug delivery to bone cells and subcellular organelles. We envision that nanotechnology-based drug delivery will serve as a powerful tool for developing treatments for currently incurable bone diseases.
骨骼是人体的主要器官之一；它支撑和保护其他器官，产生血细胞，储存矿物质，并调节激素。因此，骨骼疾病会导致患者严重的发病率、并发症或死亡率。然而，尽管骨病（如骨关节炎（OA）、骨质疏松症（OP）、骨不连、骨癌和骨髓瘤相关骨病）的发生率很高，但对其的有效治疗仍然是一个挑战。在这篇综述中，我们根据提高药物递送效率和安全性的角度，强调了基于纳米技术的药物递送在骨病治疗方面的最新进展。我们总结了最常用于骨药物递送的纳米材料。然后，我们讨论了这些纳米材料对骨组织病变部位的靶向策略。我们还强调了基于纳米技术的药物递送到骨细胞和亚细胞细胞器。我们设想，基于纳米技术的药物递送将成为开发目前无法治愈的骨病治疗方法的有力工具。
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